QuickView for CHRM1 (gene)

Gene Symbol:

CHRM1 Homo sapiens

Full name:

cholinergic receptor muscarinic 1

Synonyms:

HM1, M1, M1R, muscarinic acetylcholine receptor M1, acetylcholine receptor, muscarinic 1

Genomic Location:

Chr 11: 62432727-62445588

Description:

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence man...

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The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  TGANTCA_AP1_C ,  STAT1_02 ,  TGGNNNNNNKCCAR_UNKNOWN ,  AREB6_02 ,  VDR_Q3 ,  MYC_Q2 ,  CACGTG_MYC_Q2 ,  SMAD3_Q6 ,  NKX3A_01 ,  RNCTGNYNRNCTGNY_UNKNOWN ,  ARNT_02 ,  STAT1_03 ,  NKX22_01 ,  GGGAGGRR_MAZ_Q6 ,  TFIII_Q6 ,  GCTGAGT_MIR5125P ,  OCT1_Q6 ,  STAT3_02 ,  CACCCBINDINGFACTOR_Q6 ,  CAGGTA_AREB6_01 ,  P53_02 ,  CAGGTG_E12_Q6 ,  E47_02 ,  GR_Q6 ,  ATGCTGC_MIR103_MIR107 ,  MYCMAX_01 ,  AREB6_01 ,  USF_C ,  CEBPB_02 ,  AP1_Q2_01 ,  AHR_Q5 ,  HSF_Q6 ,  TGTTTGY_HNF3_Q6 ,  AHR_01 ,  AREB6_03 ,  RNGTGGGC_UNKNOWN ,  GFI1_01 ,  NMYC_01 ,  MTF1_Q4 ,  AP2REP_01 ,  AAAYRNCTG_UNKNOWN ,  GATA4_Q3 ,  SMAD4_Q6 ,  GTGGGTGK_UNKNOWN ,  CCANNAGRKGGC_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  CACBINDINGPROTEIN_Q6 ,  SMAD_Q6 ,  USF2_Q6 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-491

Cytogenetic Map:

11q12.3

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