QuickView for CIC (gene)

Gene Symbol:

CIC Homo sapiens

Full name:

capicua transcriptional repressor

Synonyms:

MRD45, protein capicua homolog

Genomic Location:

Chr 19: 47480657-47491789

Description:

The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-ter...

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The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AAGCCAT_MIR135A_MIR135B ,  CCCAGAG_MIR326 ,  LXR_DR4_Q3 ,  AP2GAMMA_01 ,  ACTTTAT_MIR1425P ,  COUP_01 ,  AP2ALPHA_01 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  GGGAGGRR_MAZ_Q6 ,  CAGGTA_AREB6_01 ,  LFA1_Q6 ,  CAGGTG_E12_Q6 ,  AP2_Q6_01 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  MYOGENIN_Q6 ,  WTTGKCTG_UNKNOWN ,  ATAACCT_MIR154 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  ER_Q6_01 ,  LXR_Q3 ,  AACTTT_UNKNOWN ,  ER_Q6 ,  DR4_Q2 ,  PAX4_01 ,  CACTTTG_MIR520G_MIR520H

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-490

Cytogenetic Map:

19q13.2

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