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QuickView for CISS1 (gene)


Gene Symbol:
CRLF1 Homo sapiens Homo sapiens
Full name:
cytokine receptor like factor 1
Synonyms:
CISS, CISS1, CLF, CLF-1, NR6, zcytor5, cytokine receptor-like factor 1, class I cytokine receptor, cytokine type 1 receptor CRLP-1, cytokine-like factor 1
Genomic Location:
Chr 19: 18565047-18578660
Description:
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrom...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 19
19p13.11


Protein Names
Q9UHH5
O75462



GO Molecular Function

cytokine binding | transmembrane signaling receptor activity | signaling receptor binding | cytokine receptor binding | molecular function regulator | signaling receptor activity | protein heterodimerization activity | ciliary neurotrophic factor receptor binding | cytokine receptor activity | protein binding | receptor regulator activity | protein dimerization activity | receptor ligand activity | cytokine activity

GO Biological Process

response to cytokine | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | negative regulation of neuron death | negative regulation of cellular process | positive regulation of phosphate metabolic process | regulation of neuron death | cellular process | negative regulation of apoptotic process | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | tissue development | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | epithelium development | urogenital system development | response to stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | positive regulation of JAK-STAT cascade | regulation of cell proliferation | kidney development | molecular function regulator | negative regulation of neuron apoptotic process | system development | regulation of signal transduction | ureteric bud development | multicellular organism development | regulation of phosphorylation | kidney epithelium development | regulation of motor neuron apoptotic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | positive regulation of STAT cascade | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | mesonephric epithelium development | mesonephros development | cytokine receptor activity | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | positive regulation of tyrosine phosphorylation of STAT protein | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of protein phosphorylation | renal system development | negative regulation of motor neuron apoptotic process | regulation of signaling receptor activity | receptor regulator activity | positive regulation of protein modification process | response to organic substance | regulation of JAK-STAT cascade | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | negative regulation of programmed cell death | receptor ligand activity | cytokine activity | animal organ development | regulation of phosphate metabolic process | interleukin-27-mediated signaling pathway | regulation of cell communication | signaling | positive regulation of phosphorylation | developmental process | tube development | positive regulation of metabolic process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | positive regulation of signaling | signal transduction | regulation of signaling | mesonephric tubule development | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

CRLF-CLCF1 complex | cell | external side of plasma membrane | cytoplasm | receptor complex | protein-containing complex | plasma membrane | extracellular region | extracellular space | cell periphery | cytosol | cell surface | intracellular | membrane