QuickView for CITED4 (gene)

Gene Symbol:

CITED4 Homo sapiens

Full name:

Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4

Synonyms:

cbp/p300-interacting transactivator 4, MRG-2, MSG1-related protein 2, transcriptional co-activator 4

Genomic Location:

Chr 1: 41099315-41100605

Description:

The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a c...

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The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RYTTCCTG_ETS2_B ,  P53_DECAMER_Q2 ,  TTGCWCAAY_CEBPB_02 ,  GATA_C ,  YTATTTTNR_MEF2_02 ,  STAT6_02 ,  CEBP_Q2_01 ,  NKX22_01 ,  P53_02 ,  NF1_Q6 ,  GGGCGGR_SP1_Q6 ,  CEBPB_02 ,  STAT_01 ,  CEBP_Q3 ,  CTGAGCC_MIR24 ,  TTCYNRGAA_STAT5B_01 ,  ICSBP_Q6 ,  STAT5A_01 ,  STAT5A_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-24

Cytogenetic Map:

1p34.2::1p35-p34

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