QuickView for CLIP-170 (gene)
- Gene Symbol:
- CLIP1
Homo sapiens - Full name:
- CAP-Gly domain containing linker protein 1
- Synonyms:
- CLIP, CLIP-170, CLIP170, CYLN1, RSN, CAP-Gly domain-containing linker protein 1, cytoplasmic linker protein 1, cytoplasmic linker protein 170 alpha-2, cytoplasmic linker protein CLIP-170, restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
- Genomic Location:
- Chr 12: 121321934-121473069
- Description:
-
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
12q24.31
GO Molecular Function
cation binding | cytoskeletal protein binding | identical protein binding | ion binding | microtubule plus-end binding | protein binding | protein homodimerization activity | zinc ion binding | protein dimerization activity | transition metal ion binding | microtubule binding | tubulin binding | metal ion binding
GO Biological Process
regulation of supramolecular fiber organization | regulation of microtubule polymerization or depolymerization | positive regulation of cellular component organization | protein localization to cell periphery | microtubule bundle formation | protein localization to membrane raft | establishment of localization | microtubule cytoskeleton organization | regulation of organelle organization | membrane organization | intracellular transport | microtubule-based process | cellular process | positive regulation of microtubule polymerization | localization | protein transport | macromolecule localization | establishment of localization in cell | regulation of cellular process | regulation of protein complex assembly | cellular component organization | intracellular protein transport | protein transport into membrane raft | cellular localization | positive regulation of organelle organization | protein transport within lipid bilayer | localization within membrane | protein localization to membrane | organic substance transport | cell cycle | peptide transport | positive regulation of protein complex assembly | positive regulation of cytoskeleton organization | regulation of microtubule-based process | establishment of protein localization to membrane | mitotic cell cycle | regulation of microtubule polymerization | positive regulation of supramolecular fiber organization | cellular protein localization | amide transport | positive regulation of cellular component biogenesis | cytoskeleton organization | establishment of protein localization | protein localization to plasma membrane raft | protein localization | cellular macromolecule localization | organelle organization | positive regulation of protein polymerization | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization | protein transport into plasma membrane raft
GO Cellular Component
intermediate filament | supramolecular fiber | chromosome | intracellular membrane-bounded organelle | ruffle | organelle membrane | microtubule organizing center | macropinosome | chromosome, centromeric region | cytoplasmic vesicle | cell | kinetochore | microtubule | cytoplasm | cytoplasmic microtubule | intracellular organelle | microtubule plus-end | intermediate filament cytoskeleton | centrosome | protein-containing complex | cell projection | endomembrane system | nuclear envelope | cell leading edge | vesicle | microtubule cytoskeleton | endosome | membrane-bounded organelle | nucleus | organelle | vesicle membrane | cytosol | intracellular vesicle | cytoskeleton | intracellular | microtubule end | membrane | supramolecular complex | cytoplasmic vesicle membrane
