QuickView for CLK2 (gene)

Gene Symbol:

CLK2 Homo sapiens

Full name:

CDC like kinase 2

Synonyms:

dual specificity protein kinase CLK2, CLK kinase

Genomic Location:

Chr 1: 153499283-153509905

Description:

This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locu...

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This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGTGAAG_MIR412 ,  TGCAAAC_MIR452 ,  GCACCTT_MIR18A_MIR18B ,  YY1_Q6 ,  CCTGTGA_MIR513 ,  CACCAGC_MIR138 ,  ACTACCT_MIR196A_MIR196B ,  NKX61_01 ,  AAAGACA_MIR511 ,  TAATTA_CHX10_01 ,  YTAATTAA_LHX3_01 ,  CTGAGCC_MIR24 ,  AAAGGAT_MIR501 ,  CCATCCA_MIR432 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  GGCAGTG_MIR3243P ,  ACACTGG_MIR199A_MIR199B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-29

Cytogenetic Map:

1q22

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