QuickView for CMKBR1 (gene)

Gene Symbol:

CCR1 Homo sapiens

Full name:

C-C motif chemokine receptor 1

Synonyms:

CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1, C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, LD78 receptor, MIP-1alpha-R, RANTES receptor, RANTES-R, chemokine (C-C motif) receptor 1, macrophage inflammatory protein 1-alpha receptor

Genomic Location:

Chr 3: 46218204-46224836

Description:

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractan...

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This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF4ALPHA_Q6 ,  RYTTCCTG_ETS2_B ,  AML_Q6 ,  WGTTNNNNNAAA_UNKNOWN ,  CTTTGA_LEF1_Q2 ,  RACCACAR_AML_Q6 ,  AACTTT_UNKNOWN ,  COREBINDINGFACTOR_Q6 ,  TCF11_01

Cytogenetic Map:

3p21.31

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