QuickView for COL7A1 (gene)

Gene Symbol:

COL7A1 Homo sapiens

Full name:

collagen type VII alpha 1 chain

Synonyms:

EBD1, EBDCT, EBR1, NDNC8, collagen alpha-1(VII) chain, LC collagen, collagen VII, alpha-1 polypeptide, collagen, type VII, alpha 1, long-chain collagen

Genomic Location:

Chr 3: 48576510-48607597

Description:

This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with al...

View Full Description

This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AP1_C ,  TGIF_01 ,  TGANTCA_AP1_C ,  ZIC1_01 ,  GCANCTGNY_MYOD_Q6 ,  GTGACTT_MIR224 ,  ZIC3_01 ,  GGGCATT_MIR365 ,  RP58_01 ,  AP1_01 ,  AP4_Q6 ,  BACH2_01 ,  GGGCGGR_SP1_Q6 ,  BACH1_01 ,  ZIC2_01 ,  CTGCAGY_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  CAGCTG_AP4_Q5 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  GGCAGTG_MIR3243P ,  AP1_Q4_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-29

Cytogenetic Map:

3p21.31

search → result