QuickView for CREB-2 (gene)

Gene Symbol:

ATF4 Homo sapiens

Full name:

activating transcription factor 4

Synonyms:

CREB-2, CREB2, TAXREB67, TXREB, cyclic AMP-dependent transcription factor ATF-4, DNA-binding protein TAXREB67, cAMP response element-binding protein 2, cAMP-dependent transcription factor ATF-4, cAMP-responsive element-binding protein 2, cyclic AMP-responsive element-binding protein 2, tax-responsive enhancer element B67, tax-responsive enhancer element-binding protein 67

Genomic Location:

Chr 22: 38246515-38248637

Description:

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs ...

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This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  NFMUE1_Q6 ,  TGANTCA_AP1_C ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  SRF_Q6 ,  MAX_01 ,  TTTGTAG_MIR520D ,  ATCMNTCCGY_UNKNOWN ,  ARNT_02 ,  COUP_01 ,  GCCATNTTG_YY1_Q6 ,  TATAAA_TATA_01 ,  SREBP1_01 ,  YY1_Q6 ,  HNF4_Q6 ,  BACH2_01 ,  RAAGNYNNCTTY_UNKNOWN ,  NF1_Q6_01 ,  USF_01 ,  WGGAATGY_TEF1_Q6 ,  CTGCAGY_UNKNOWN ,  SRF_Q5_01 ,  CTTTGT_LEF1_Q2 ,  USF_02 ,  STAT5A_02

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Cytogenetic Map:

22q13.1

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