QuickView for CREB-RP (gene)
- Gene Symbol:
- ATF6B
Homo sapiens - Full name:
- activating transcription factor 6 beta
- Synonyms:
- CREB-RP, CREBL1, G13, cyclic AMP-dependent transcription factor ATF-6 beta, Creb-related protein, cAMP response element-binding protein-related protein, cAMP-dependent transcription factor ATF-6 beta, cAMP-responsive element-binding protein-like 1, protein G13
- Genomic Location:
- Chr 6: 32191016-32203995
- Description:
-
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally foun...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
6p21.32
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | enhancer binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | cAMP response element binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | positive regulation of macromolecule biosynthetic process | response to endoplasmic reticulum stress | regulation of ATF6-mediated unfolded protein response | regulation of endoplasmic reticulum unfolded protein response | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ATF6-mediated unfolded protein response | positive regulation of cellular biosynthetic process | cellular process | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | negative regulation of signaling | endoplasmic reticulum unfolded protein response | negative regulation of response to endoplasmic reticulum stress | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to unfolded protein | response to topologically incorrect protein | cellular aromatic compound metabolic process | cellular response to topologically incorrect protein | response to stimulus | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | response to stress | regulation of response to endoplasmic reticulum stress | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | negative regulation of endoplasmic reticulum unfolded protein response | positive regulation of RNA biosynthetic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | nitrogen compound metabolic process | regulation of signal transduction | ER-nucleus signaling pathway | regulation of gene expression | cellular response to stress | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | cell communication | regulation of cellular metabolic process | negative regulation of ATF6-mediated unfolded protein response | regulation of RNA metabolic process | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | response to organic substance | metabolic process | regulation of DNA-templated transcription in response to stress | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transcription, DNA-templated | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of transcription from RNA polymerase II promoter in response to stress | response to unfolded protein | cellular macromolecule biosynthetic process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
nuclear transcription factor complex | integral component of membrane | intracellular membrane-bounded organelle | RNA polymerase II transcription factor complex | cell | integral component of endoplasmic reticulum membrane | nuclear lumen | transcription factor complex | intrinsic component of membrane | nucleolus | cytoplasm | intracellular organelle | intrinsic component of endoplasmic reticulum membrane | endoplasmic reticulum | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | protein-DNA complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular | membrane
