QuickView for CRK;jsessionid=41CB855447F633E5CC0528BD4BC429B6 (gene)

Gene Symbol:

CRK Homo sapiens

Full name:

CRK proto-oncogene, adaptor protein

Synonyms:

CRKII, p38, adapter molecule crk, proto-oncogene c-Crk, v-crk avian sarcoma virus CT10 oncogene homolog, v-crk sarcoma virus CT10 oncogene-like protein

Genomic Location:

Chr 17: 1272190-1306294

Description:

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The...

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This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GCATTTG_MIR105 ,  STAT1_02 ,  RYTTCCTG_ETS2_B ,  AP3_Q6 ,  STAT6_02 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  CIZ_01 ,  ACTTTAT_MIR1425P ,  TAGCTTT_MIR9 ,  STAT1_03 ,  TTF1_Q6 ,  NKX22_01 ,  CTACTAG_MIR325 ,  MYCMAX_B ,  CREB_Q3 ,  ACCAATC_MIR509 ,  GCTGAGT_MIR5125P ,  TAATGTG_MIR323 ,  CACCCBINDINGFACTOR_Q6 ,  GGGYGTGNY_UNKNOWN ,  GGATTA_PITX2_Q2 ,  ETS2_B ,  AP1FJ_Q2 ,  TGCGCANK_UNKNOWN ,  E2F_Q4 ,  ATTCTTT_MIR186 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GGGCGGR_SP1_Q6 ,  GCGNNANTTCC_UNKNOWN ,  TGCCAAR_NF1_Q6 ,  KCCGNSWTTT_UNKNOWN ,  NRF1_Q6 ,  PTF1BETA_Q6 ,  AATGTGA_MIR23A_MIR23B ,  AGTCTAG_MIR151 ,  AP2_Q6 ,  CP2_02 ,  SMAD4_Q6 ,  CCGNMNNTNACG_UNKNOWN ,  ISRE_01 ,  SMAD_Q6 ,  ELK1_02 ,  SRF_C ,  ACACTAC_MIR1423P ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-126 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-325 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-151 ,  Predicted Gene Targets for miR-410

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Cytogenetic Map:

17p13.3

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