QuickView for CSCD (gene)

Gene Symbol:

DCN Homo sapiens

Full name:

decorin

Synonyms:

CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B, decorin, bone proteoglycan II, dermatan sulphate proteoglycans II, proteoglycan core protein, small leucine-rich protein 1B

Genomic Location:

Chr 12: 90063166-90100937

Description:

This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple...

View Full Description

This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  RTAAACA_FREAC2_01 ,  HNF4ALPHA_Q6 ,  OCT1_05 ,  MZF1_01 ,  YATGNWAAT_OCT_C ,  GATA_C ,  CEBP_Q2_01 ,  IPF1_Q4 ,  WGTTNNNNNAAA_UNKNOWN ,  AP1_Q6 ,  CTTTGA_LEF1_Q2 ,  CEBPB_01 ,  AP1_Q6_01 ,  FREAC3_01 ,  CAGGTG_E12_Q6 ,  AP1FJ_Q2 ,  OCT1_03 ,  OCT1_02 ,  POU3F2_02 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  CEBP_C ,  GTGGGTGK_UNKNOWN ,  AP1_Q2 ,  CACBINDINGPROTEIN_Q6 ,  AACTTT_UNKNOWN ,  YAATNANRNNNCAG_UNKNOWN ,  GGGTGGRR_PAX4_03

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

12q21.33

search → result