QuickView for CSF1R;jsessionid=3BAA5BC29BEC0EF40837DEE2E83EF9A4 (gene)

Gene Symbol:

CSF1R Homo sapiens

Full name:

colony stimulating factor 1 receptor

Synonyms:

C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, macrophage colony-stimulating factor 1 receptor, CD115 antigen, CSF-1 receptor, FMS proto-oncogene, McDonough feline sarcoma viral (v-fms) oncogene homolog, macrophage colony stimulating factor I receptor, proto-oncogene c-Fms

Genomic Location:

Chr 5: 149413051-149473128

Description:

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosph...

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The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGCC_MIR34A_MIR34C_MIR449 ,  TGANTCA_AP1_C ,  GCANCTGNY_MYOD_Q6 ,  NFKAPPAB65_01 ,  AGCATTA_MIR155 ,  GGCAGCT_MIR22 ,  AP4_Q6_01 ,  CREL_01 ,  CAGCTG_AP4_Q5 ,  AP1_Q4_01 ,  GGGNNTTTCC_NFKB_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-155

Cytogenetic Map:

5q32

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