QuickView for CSF2 (gene)
- Gene Symbol:
- CSF2
Homo sapiens - Full name:
- colony stimulating factor 2
- Synonyms:
- CSF, GMCSF, granulocyte-macrophage colony-stimulating factor, colony stimulating factor 2 (granulocyte-macrophage), granulocyte macrophage-colony stimulating factor, molgramostin, sargramostim
- Genomic Location:
- Chr 5: 131437384-131439758
- Description:
-
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial de...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
5q31.1
GO Molecular Function
guanyl-nucleotide exchange factor activity | GTPase binding | granulocyte macrophage colony-stimulating factor receptor binding | enzyme binding | signaling receptor binding | cytokine receptor binding | Ras GTPase binding | molecular function regulator | catalytic activity | protein tyrosine kinase activity | protein binding | receptor regulator activity | growth factor activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | Ras guanyl-nucleotide exchange factor activity | receptor ligand activity | protein kinase activity | cytokine activity | transferase activity | small GTPase binding | growth factor receptor binding | kinase activity
GO Biological Process
regulation of extrinsic apoptotic signaling pathway in absence of ligand | guanyl-nucleotide exchange factor activity | response to cytokine | positive regulation of cellular component organization | response to lipopolysaccharide | developmental process involved in reproduction | intracellular signal transduction | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | peptidyl-amino acid modification | establishment of localization | regulation of immune system process | myeloid cell differentiation | negative regulation of cellular process | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | fluid transport | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | regulation of organelle organization | regulation of circadian sleep/wake cycle | histamine secretion | cellular process | secretion | cellular response to granulocyte macrophage colony-stimulating factor stimulus | localization | negative regulation of signaling | reproductive system development | immune system development | azole transport | negative regulation of nucleic acid-templated transcription | negative regulation of apoptotic process | myeloid dendritic cell differentiation | regulation of tyrosine phosphorylation of STAT protein | regulation of cytolysis | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | transepithelial transport | response to inorganic substance | negative regulation of cellular metabolic process | regulation of behavior | regulation of cell differentiation | histamine transport | negative regulation of apoptotic signaling pathway | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | regulation of protein complex assembly | cellular response to molecule of bacterial origin | positive regulation of cellular protein metabolic process | MAPK cascade | response to stimulus | regulation of macrophage derived foam cell differentiation | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | positive regulation of JAK-STAT cascade | regulation of cell proliferation | reproduction | response to molecule of bacterial origin | myeloid dendritic cell activation | negative regulation of metabolic process | hemopoiesis | protein modification process | embryo development | macromolecule modification | molecular function regulator | embryonic placenta development | regulation of nucleic acid-templated transcription | leukocyte differentiation | response to external biotic stimulus | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | multicellular organism development | phosphorus metabolic process | positive regulation of organelle assembly | response to granulocyte macrophage colony-stimulating factor | positive regulation of podosome assembly | regulation of phosphorylation | monocyte differentiation | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | organic substance transport | response to lipid | myeloid leukocyte differentiation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | positive regulation of STAT cascade | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | positive regulation of cell differentiation | negative regulation of extrinsic apoptotic signaling pathway | negative regulation of cytolysis | granulocyte differentiation | cellular response to cytokine stimulus | positive regulation of interleukin-23 production | regulation of cellular protein metabolic process | phosphorylation | regulation of interleukin-23 production | regulation of apoptotic signaling pathway | regulation of circadian sleep/wake cycle, sleep | protein phosphorylation | response to silicon dioxide | phosphate-containing compound metabolic process | response to bacterium | chordate embryonic development | cell communication | regulation of cellular metabolic process | positive regulation of tyrosine phosphorylation of STAT protein | positive regulation of macrophage derived foam cell differentiation | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | protein tyrosine kinase activity | regulation of signaling receptor activity | receptor regulator activity | regulation of podosome assembly | protein metabolic process | positive regulation of protein modification process | response to organic substance | neutrophil differentiation | regulation of hemopoiesis | epithelial fluid transport | regulation of JAK-STAT cascade | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | growth factor activity | metabolic process | dendritic cell differentiation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | Ras guanyl-nucleotide exchange factor activity | receptor ligand activity | macrophage activation | immune response | protein kinase activity | positive regulation of cellular component biogenesis | cytokine activity | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | regulation of phosphate metabolic process | positive regulation of cytokine production | cell activation | response to fluid shear stress | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | cation transport | response to biotic stimulus | ammonium transport | regulation of circadian rhythm | reproductive structure development | regulation of developmental process | kinase activity | developmental process | cellular protein modification process | neurotransmitter transport | in utero embryonic development | positive regulation of metabolic process | ion transport | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | placenta development | cellular response to organic substance | regulation of cell death | regulation of organelle assembly | negative regulation of cell death | regulation of cellular component organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | intracellular organelle | extracellular region | membrane-bounded organelle | organelle | extracellular space | intracellular
