QuickView for CSO (gene)

Gene Symbol:

TWIST1 Homo sapiens

Full name:

twist family bHLH transcription factor 1

Synonyms:

ACS3, BPES2, BPES3, CRS, CRS1, CSO, SCS, SWCOS, TWIST, bHLHa38, twist-related protein 1, B-HLH DNA binding protein, H-twist, TWIST homolog of drosophila, class A basic helix-loop-helix protein 38, twist basic helix-loop-helix transcription factor 1, twist homolog 1

Genomic Location:

Chr 7: 19121616-19123820

Description:

This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate ...

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This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  IRF1_01 ,  FREAC7_01 ,  HNF3ALPHA_Q6 ,  STAT4_01 ,  PU1_Q6 ,  GATA1_03 ,  OCT1_B ,  ETS_Q4 ,  ATF6_01 ,  OCT1_04 ,  FOX_Q2 ,  RSRFC4_01 ,  HFH3_01 ,  OCT_Q6 ,  POU3F2_01 ,  YTATTTTNR_MEF2_02 ,  STAT6_02 ,  TTCNRGNNNNTTC_HSF_Q6 ,  FOXD3_01 ,  EVI1_04 ,  RSRFC4_Q2 ,  TTF1_Q6 ,  CTAWWWATA_RSRFC4_Q2 ,  MAF_Q6 ,  GATA1_04 ,  MEF2_02 ,  TCTAGAG_MIR517 ,  TATAAA_TATA_01 ,  CDPCR3HD_01 ,  TCTGATA_MIR361 ,  TITF1_Q3 ,  CDX2_Q5 ,  STAT5B_01 ,  ETS2_B ,  TST1_01 ,  TATA_C ,  NKX62_Q2 ,  GAGCTGG_MIR337 ,  HNF3_Q6 ,  CTCAAGA_MIR526B ,  FOXJ2_01 ,  PITX2_Q2 ,  HIF1_Q5 ,  NERF_Q2 ,  MGGAAGTG_GABP_B ,  CTCTGGA_MIR520A_MIR525 ,  IRF_Q6 ,  PAX6_01 ,  HFH4_01 ,  SOX5_01 ,  PAX8_B ,  AGTCTAG_MIR151 ,  AACATTC_MIR4093P ,  TTGTTT_FOXO4_01 ,  PIT1_Q6 ,  GATA1_05 ,  MEF2_03 ,  TEF_Q6 ,  RGAGGAARY_PU1_Q6 ,  IK1_01 ,  PAX_Q6 ,  GTGGGTGK_UNKNOWN ,  RYAAAKNNNNNNTTGW_UNKNOWN ,  ICSBP_Q6 ,  SMAD_Q6 ,  P300_01 ,  ETS1_B ,  ELF1_Q6 ,  HNF6_Q6 ,  TCCAGAG_MIR518C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-151 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

7p21.1

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