QuickView for CTCF (gene)

Gene Symbol:

CTCF Homo sapiens

Full name:

CCCTC-binding factor

Synonyms:

MRD21, transcriptional repressor CTCF, 11 zinc finger transcriptional repressor, 11-zinc finger protein, CCCTC-binding factor (zinc finger protein), CTCFL paralog

Genomic Location:

Chr 16: 66153965-66230589

Description:

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a hist...

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This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGTSACG_PAX3_B ,  NKX25_01 ,  RTAAACA_FREAC2_01 ,  SMTTTTGT_UNKNOWN ,  TGIF_01 ,  GATA1_03 ,  GATA1_01 ,  CCCAGAG_MIR326 ,  TCANNTGAY_SREBP1_01 ,  RYTTCCTG_ETS2_B ,  AREB6_02 ,  FOX_Q2 ,  VDR_Q3 ,  E2F1_Q4_01 ,  ZF5_01 ,  STAT6_02 ,  LXR_DR4_Q3 ,  TGTGTGA_MIR377 ,  ATF4_Q2 ,  TTTGTAG_MIR520D ,  HP1SITEFACTOR_Q6 ,  E2F_Q6_01 ,  AP2GAMMA_01 ,  GTACTGT_MIR101 ,  GTAAACC_MIR2995P ,  TAAYNRNNTCC_UNKNOWN ,  AP2ALPHA_01 ,  CTCNANGTGNY_UNKNOWN ,  GCCATNTTG_YY1_Q6 ,  GATA1_04 ,  CREB_Q4 ,  E2F1_Q4 ,  WHN_B ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  E2F_Q6 ,  GTGACGY_E4F1_Q6 ,  E2F1_Q6_01 ,  ETS2_B ,  YY1_01 ,  EGR_Q6 ,  WYAAANNRNNNGCG_UNKNOWN ,  AP2_Q6_01 ,  ZID_01 ,  E2F_Q4 ,  YGCANTGCR_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  TGCTGAY_UNKNOWN ,  PITX2_Q2 ,  LMO2COM_02 ,  GATA6_01 ,  SPZ1_01 ,  AP2_Q3 ,  TGTTTGY_HNF3_Q6 ,  E2F_03 ,  GATA1_02 ,  KCCGNSWTTT_UNKNOWN ,  PTF1BETA_Q6 ,  E2F_Q4_01 ,  NCX_01 ,  AATGTGA_MIR23A_MIR23B ,  EN1_01 ,  AP2_Q6 ,  CETS1P54_01 ,  YTAAYNGCT_UNKNOWN ,  E2F1DP1RB_01 ,  CAAGGAT_MIR362 ,  YY1_02 ,  GATA1_05 ,  GAGCCAG_MIR149 ,  TEF_Q6 ,  CREB_Q2 ,  ACAWNRNSRCGG_UNKNOWN ,  TCCATTKW_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  EGR1_01 ,  TBP_01 ,  RCGCANGCGY_NRF1_Q6 ,  LXR_Q3 ,  FOXM1_01 ,  AAACCAC_MIR140 ,  AACTTT_UNKNOWN ,  E2F_Q3 ,  E2F_Q3_01 ,  HNF1_Q6 ,  ELF1_Q6 ,  FREAC4_01 ,  RACTNNRTTTNC_UNKNOWN ,  GGGTGGRR_PAX4_03 ,  TAXCREB_01 ,  E2F1_Q6 ,  ATGTAGC_MIR221_MIR222

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-362 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

16q22.1

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