QuickView for CTH (gene)
- Gene Symbol:
- CTH
Homo sapiens - Full name:
- cystathionine gamma-lyase
- Synonyms:
- cystathionine gamma-lyase, cystathionase (cystathionine gamma-lyase), cysteine desulfhydrase, cysteine-protein sulfhydrase, gamma-cystathionase, homoserine deaminase, homoserine dehydratase
- Genomic Location:
- Chr 1: 70649543-70677841
- Description:
-
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding dif...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
1p31.1
GO Molecular Function
homocysteine desulfhydrase activity | cofactor binding | vitamin binding | transferase activity, transferring alkyl or aryl (other than methyl) groups | coenzyme binding | L-cysteine desulfhydrase activity | lyase activity | pyridoxal phosphate binding | catalytic activity | carbon-sulfur lyase activity | anion binding | identical protein binding | ion binding | organic cyclic compound binding | vitamin B6 binding | protein binding | transferase activity | cystathionine gamma-lyase activity | drug binding | calmodulin binding | heterocyclic compound binding | L-cystine L-cysteine-lyase (deaminating) | cystathionine gamma-synthase activity | small molecule binding
GO Biological Process
protein homooligomerization | response to endoplasmic reticulum stress | response to cytokine | sulfur compound metabolic process | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | peptidyl-amino acid modification | negative regulation of cellular process | positive regulation of developmental process | cellular amino acid catabolic process | cellular process | organic substance catabolic process | toxin metabolic process | protein-pyridoxal-5-phosphate linkage | negative regulation of signaling | serine family amino acid metabolic process | cysteine biosynthetic process | protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine | endoplasmic reticulum unfolded protein response | negative regulation of apoptotic process | sulfur amino acid biosynthetic process | regulation of cell differentiation | positive regulation of muscle cell differentiation | negative regulation of apoptotic signaling pathway | cellular amino acid metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | cellular response to unfolded protein | response to topologically incorrect protein | cellular component organization | cellular response to topologically incorrect protein | regulation of vasculature development | response to stimulus | carboxylic acid catabolic process | response to stress | cellular amino acid biosynthetic process | cellular component assembly | protein modification process | protein-cofactor linkage | cellular biosynthetic process | macromolecule modification | serine family amino acid biosynthetic process | regulation of nucleic acid-templated transcription | sulfur amino acid metabolic process | nitrogen compound metabolic process | regulation of signal transduction | protein complex oligomerization | cysteine biosynthetic process via cystathionine | regulation of gene expression | cellular response to stress | regulation of smooth muscle cell differentiation | regulation of nitrogen compound metabolic process | small molecule metabolic process | methionine metabolic process | positive regulation of intracellular signal transduction | protein homotetramerization | positive regulation of aortic smooth muscle cell differentiation | positive regulation of smooth muscle cell differentiation | positive regulation of cell differentiation | cellular response to cytokine stimulus | biosynthetic process | protein tetramerization | regulation of aortic smooth muscle cell differentiation | regulation of apoptotic signaling pathway | cell communication | regulation of cellular metabolic process | positive regulation of signal transduction | transsulfuration | regulation of RNA metabolic process | drug metabolic process | carboxylic acid metabolic process | positive regulation of molecular function | protein-containing complex assembly | protein metabolic process | response to organic substance | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | methionine biosynthetic process | metabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | peptidyl-lysine modification | organic substance metabolic process | positive regulation of NF-kappaB transcription factor activity | homoserine metabolic process | hydrogen sulfide biosynthetic process | organonitrogen compound catabolic process | regulation of cell communication | homocysteine metabolic process | negative regulation of signal transduction | cellular response to leukemia inhibitory factor | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | organic acid metabolic process | cellular protein metabolic process | response to unfolded protein | sulfur amino acid catabolic process | regulation of developmental process | cysteine metabolic process | regulation of muscle cell differentiation | cellular protein modification process | sulfur compound catabolic process | toxin biosynthetic process | positive regulation of vascular smooth muscle cell differentiation | cellular metabolic process | protein sulfhydration | cellular response to organic substance | hydrogen sulfide metabolic process | regulation of cell death | negative regulation of cell death | 'de novo' L-methionine biosynthetic process | regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process
GO Cellular Component
cell | cytoplasm | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cytosol | intracellular
