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QuickView for CTHRC1;jsessionid=3E2E506CEA84FF68077630D678ADE7D1 (gene)


Gene Symbol:
CTHRC1 Homo sapiens Homo sapiens
Full name:
collagen triple helix repeat containing 1
Synonyms:
collagen triple helix repeat-containing protein 1
Genomic Location:
Chr 8: 104452962-104464393
Description:
This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Danio rerio Pan troglodytes Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 8
8q22.3


Transcripts Names
NM_138455
NM_001256099
XM_011516824
Protein Names
Q96CG8
Q8IX63
Q6UW91
G3V141



GO Molecular Function

signaling receptor binding | frizzled binding | protein binding | G-protein coupled receptor binding | Wnt-protein binding

GO Biological Process

inner ear morphogenesis | cell motility | establishment of planar polarity involved in neural tube closure | morphogenesis of an epithelium | regulation of osteoblast proliferation | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | nervous system development | neurogenesis | bone remodeling | ossification involved in bone remodeling | generation of neurons | cellular process | localization | epithelial tube morphogenesis | tissue remodeling | negative regulation of signaling | neuron development | regulation of canonical Wnt signaling pathway | tissue development | regulation of binding | regulation of cell differentiation | morphogenesis of a polarized epithelium | regulation of cellular process | regulation of osteoblast differentiation | epithelium development | regulation of establishment of planar polarity | cellular component organization | positive regulation of protein binding | response to stimulus | embryonic epithelial tube formation | regulation of cell proliferation | tube morphogenesis | epithelial tube formation | inner ear receptor cell differentiation | Wnt signaling pathway, planar cell polarity pathway | embryo development | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | locomotion | system development | regulation of signal transduction | Wnt signaling pathway | multicellular organism development | cell migration | inner ear receptor cell development | inner ear receptor cell stereocilium organization | regulation of ossification | mechanoreceptor differentiation | neural tube closure | animal organ morphogenesis | neural tube formation | positive regulation of cell differentiation | non-canonical Wnt signaling pathway | neural tube development | positive regulation of ossification | sensory organ development | chordate embryonic development | cell communication | inner ear development | positive regulation of osteoblast proliferation | positive regulation of cell proliferation | embryo development ending in birth or egg hatching | cochlea morphogenesis | establishment of planar polarity | embryonic morphogenesis | positive regulation of molecular function | positive regulation of osteoblast differentiation | neuron differentiation | embryonic organ morphogenesis | tissue morphogenesis | regulation of animal organ morphogenesis | establishment of tissue polarity | anatomical structure development | cell surface receptor signaling pathway | cell projection organization | embryonic organ development | ear development | morphogenesis of embryonic epithelium | neuron projection development | animal organ development | regulation of Wnt signaling pathway | positive regulation of binding | anatomical structure formation involved in morphogenesis | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of protein binding | cell development | anatomical structure morphogenesis | regulation of developmental process | developmental process | negative regulation of canonical Wnt signaling pathway | tube development | cochlea development | tube closure | tube formation | negative regulation of Wnt signaling pathway | ossification | establishment of planar polarity of embryonic epithelium | ear morphogenesis | signal transduction | regulation of signaling | multicellular organismal process

GO Cellular Component

extracellular matrix | cell | cytoplasm | protein-containing complex | collagen trimer | extracellular region | extracellular space | intracellular