QuickView for CTNND2;jsessionid=2862E1B697B0137C1F225DEB22E2B8CC (gene)

Gene Symbol:

CTNND2 Homo sapiens

Full name:

catenin delta 2

Synonyms:

GT24, NPRAP, catenin delta-2, T-cell delta-catenin, catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein), neurojungin

Genomic Location:

Chr 5: 11024952-11957110

Description:

This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is ove...

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This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  SMTTTTGT_UNKNOWN ,  TTANTCA_UNKNOWN ,  GNCF_01 ,  ZIC1_01 ,  RSRFC4_01 ,  E2F1_Q4_01 ,  RSRFC4_Q2 ,  IPF1_Q4 ,  CAGTGTT_MIR141_MIR200A ,  E2F_Q6_01 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  TACTTGA_MIR26A_MIR26B ,  ATGTACA_MIR493 ,  TAGCTTT_MIR9 ,  IRF1_Q6 ,  GR_Q6_01 ,  CTAWWWATA_RSRFC4_Q2 ,  E2F1_Q4 ,  CREB_Q3 ,  TAAWWATAG_RSRFC4_Q2 ,  COMP1_01 ,  GGGAGGRR_MAZ_Q6 ,  TCTGATA_MIR361 ,  E2F_Q6 ,  E2F1_Q6_01 ,  P53_02 ,  GR_Q6 ,  E2F_Q4 ,  CREB_02 ,  ATGTTAA_MIR302C ,  ACTGCCT_MIR34B ,  OCT1_03 ,  YCATTAA_UNKNOWN ,  E2F_Q4_01 ,  AP2_Q6 ,  TAATTA_CHX10_01 ,  GR_01 ,  YTAAYNGCT_UNKNOWN ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  MEF2_03 ,  CTGCAGY_UNKNOWN ,  T3R_Q6 ,  TCCATTKW_UNKNOWN ,  YWATTWNNRGCT_UNKNOWN ,  BRN2_01 ,  AACTTT_UNKNOWN ,  E2F_Q3 ,  TGACATY_UNKNOWN ,  E2F_Q3_01 ,  GTTAAAG_MIR302B ,  GGGTGGRR_PAX4_03 ,  E2F1_Q6 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-328 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

5p15.2

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