QuickView for CX3CL1 (gene)

Gene Symbol:

CX3CL1 Homo sapiens

Full name:

C-X3-C motif chemokine ligand 1

Synonyms:

ABCD-3, C3Xkine, CXC3, CXC3C, NTN, NTT, SCYD1, fractalkine, neurotactin, fractalkine, C-X3-C motif chemokine 1, CX3C membrane-anchored chemokine, chemokine (C-X3-C motif) ligand 1, small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin), small inducible cytokine subfamily D (Cys-X3-Cys), member-1, small-inducible cytokine D1

Genomic Location:

Chr 16: 55963915-55976457

Description:

This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like st...

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This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemotactic cytokine. The mature form of this protein can be cleaved at the cell surface, yielding different soluble forms that can interact with the G-protein coupled receptor, C-X3-C motif chemokine receptor 1 gene product. This gene plays a role in a wide range of diseases, including cancer, vasculitis, neuropathies, atherosclerosis, inflammatory diseases, and in human immunodeficiency virus infections.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PU1_Q6 ,  MIF1_01 ,  SRF_Q6 ,  NGFIC_01 ,  RFX1_01 ,  TTAYRTAA_E4BP4_01 ,  EGR2_01 ,  TGACCTY_ERR1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  SRF_Q4 ,  GCM_Q2 ,  RORA1_01 ,  RYTGCNNRGNAAC_MIF1_01 ,  TATA_01 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ERR1_Q2 ,  DR4_Q2 ,  TGACCTTG_SF1_Q6 ,  SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-29

Cytogenetic Map:

16q21

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