QuickView for CXCL11 (gene)

Gene Symbol:

CXCL11 Homo sapiens

Full name:

C-X-C motif chemokine ligand 11

Synonyms:

H174, I-TAC, IP-9, IP9, SCYB11, SCYB9B, b-R1, C-X-C motif chemokine 11, beta-R1, chemokine (C-X-C motif) ligand 11, interferon gamma-inducible protein 9, interferon-inducible T-cell alpha chemoattractant, small inducible cytokine B11, small inducible cytokine subfamily B (Cys-X-Cys), member 11, small inducible cytokine subfamily B (Cys-X-Cys), member 9B

Genomic Location:

Chr 4: 77173859-77176257

Description:

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune ...

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Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF1_01 ,  NFKAPPAB_01 ,  NFKAPPAB65_01 ,  STAT5B_01 ,  STAT_01 ,  TTGTTT_FOXO4_01 ,  STAT5A_04 ,  TTCYNRGAA_STAT5B_01 ,  CREL_01 ,  STAT5A_01 ,  ISRE_01

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Cytogenetic Map:

4q21.1

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