QuickView for CXCR4 (gene)

Gene Symbol:

CXCR4 Homo sapiens

Full name:

C-X-C motif chemokine receptor 4

Synonyms:

CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS, C-X-C chemokine receptor type 4, CD184 antigen, LPS-associated protein 3, SDF-1 receptor, chemokine (C-X-C motif) receptor 4, chemokine receptor, fusin, leukocyte-derived seven transmembrane domain receptor, lipopolysaccharide-associated protein 3, neuropeptide Y receptor Y3, neuropeptide Y3 receptor, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, stromal cell-derived factor 1 receptor

Genomic Location:

Chr 2: 136588389-136592195

Description:

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammagl...

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This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_Q2 ,  CTTGTAT_MIR381 ,  SMTTTTGT_UNKNOWN ,  WGTTNNNNNAAA_UNKNOWN ,  CTTTGA_LEF1_Q2 ,  GR_Q6_01 ,  TATAAA_TATA_01 ,  RGAANNTTC_HSF1_01 ,  CAGGTA_AREB6_01 ,  LFA1_Q6 ,  CAGGTG_E12_Q6 ,  ACCAAAG_MIR9 ,  IRF_Q6 ,  AREB6_03 ,  GGCACTT_MIR519E ,  IRF7_01 ,  TEF_Q6 ,  TATA_01 ,  ICSBP_Q6 ,  RCGCANGCGY_NRF1_Q6 ,  ISRE_01 ,  GGCKCATGS_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

2q22.1

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