QuickView for CYLD (gene)

Gene Symbol:

CYLD Homo sapiens

Full name:

CYLD lysine 63 deubiquitinase

Synonyms:

BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2, ubiquitin carboxyl-terminal hydrolase CYLD, cylindromatosis (turban tumor syndrome), deubiquitinating enzyme CYLD, probable ubiquitin carboxyl-terminal hydrolase CYLD, ubiquitin specific peptidase like 2, ubiquitin thioesterase CYLD, ubiquitin thiolesterase CYLD, ubiquitin-specific-processing protease CYLD

Genomic Location:

Chr 16: 49333462-49393347

Description:

This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encodin...

View Full Description

This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  MYOD_Q6_01 ,  TTTGCAC_MIR19A_MIR19B ,  TGIF_01 ,  TTANTCA_UNKNOWN ,  CREBP1CJUN_01 ,  HOXA4_Q2 ,  PR_01 ,  GCANCTGNY_MYOD_Q6 ,  MEIS1BHOXA9_01 ,  NFKAPPAB_01 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  E2A_Q2 ,  TTAYRTAA_E4BP4_01 ,  CREB_Q4 ,  NFKAPPAB65_01 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  TATAAA_TATA_01 ,  RGAANNTTC_HSF1_01 ,  CAGGTA_AREB6_01 ,  RREB1_01 ,  ATF_01 ,  CAGGTG_E12_Q6 ,  HSF1_01 ,  LHX3_01 ,  EGR_Q6 ,  NKX62_Q2 ,  CREB_02 ,  ATF3_Q6 ,  GGGCGGR_SP1_Q6 ,  YKACATTT_UNKNOWN ,  NFY_Q6 ,  E47_01 ,  TGCCAAR_NF1_Q6 ,  SPZ1_01 ,  HSF2_01 ,  AR_Q2 ,  TAATTA_CHX10_01 ,  GR_01 ,  ATF1_Q6 ,  MYOGENIN_Q6 ,  CREB_Q2 ,  YTAATTAA_LHX3_01 ,  TGACGTCA_ATF3_Q6 ,  GTGGGTGK_UNKNOWN ,  CREL_01 ,  NFKB_Q6_01 ,  GCTNWTTGK_UNKNOWN ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  NFKB_Q6 ,  NFKB_C ,  CREB_Q2_01 ,  CREB_01 ,  GGGNNTTTCC_NFKB_Q6_01 ,  GGGTGGRR_PAX4_03 ,  TAXCREB_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-19

Cytogenetic Map:

16q12.1

search → result