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QuickView for CYP19A1 (gene)


Gene Symbol:
CYP19A1 Homo sapiens Homo sapiens
Full name:
cytochrome P450 family 19 subfamily A member 1
Synonyms:
ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM, aromatase, cytochrome P-450AROM, cytochrome P450 19A1, cytochrome P450, family 19, subfamily A, polypeptide 1, cytochrome P450, subfamily XIX (aromatization of androgens), estrogen synthase, estrogen synthetase, flavoprotein-linked monooxygenase, microsomal monooxygenase
Genomic Location:
Chr 15: 49288961-49418086
Description:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutati...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 15
15q21.2





GO Molecular Function

cofactor binding | cation binding | steroid hydroxylase activity | iron ion binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | electron transfer activity | ion binding | organic cyclic compound binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | tetrapyrrole binding | oxygen binding | transition metal ion binding | heme binding | drug binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | aromatase activity | small molecule binding

GO Biological Process

regulation of leukocyte chemotaxis | negative regulation of immune system process | developmental process involved in reproduction | regulation of localization | prostate gland growth | gonad development | female gonad development | regulation of immune system process | negative regulation of cellular process | organ growth | generation of precursor metabolites and energy | estrogen biosynthetic process | estrogen metabolic process | negative regulation of chronic inflammatory response | regulation of lipid transport | sterol metabolic process | cellular process | organic substance catabolic process | negative regulation of inflammatory response | regulation of cell motility | developmental growth | reproductive system development | regulation of estradiol secretion | regulation of chemotaxis | negative regulation of cell migration | negative regulation of macrophage migration | negative regulation of cell motility | regulation of cellular process | catabolic process | steroid hydroxylase activity | negative regulation of chemotaxis | organic cyclic compound metabolic process | steroid biosynthetic process | urogenital system development | development of primary sexual characteristics | electron transport chain | development of primary female sexual characteristics | reproduction | negative regulation of leukocyte chemotaxis | androgen metabolic process | positive regulation of hormone secretion | cellular biosynthetic process | organic hydroxy compound metabolic process | system development | reproductive process | multicellular organism development | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | hormone biosynthetic process | mammary gland development | steroid catabolic process | lipid metabolic process | regulation of hormone levels | regulation of hormone secretion | electron transfer activity | positive regulation of secretion | regulation of cell migration | small molecule metabolic process | regulation of cellular component movement | cellular ketone metabolic process | biosynthetic process | lipid biosynthetic process | positive regulation of lipid localization | testosterone biosynthetic process | regulation of leukocyte migration | androgen catabolic process | female genitalia development | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | regulation of locomotion | positive regulation of transport | genitalia development | positive regulation of estradiol secretion | gland development | hormone catabolic process | anatomical structure development | regulation of chronic inflammatory response | metabolic process | oxidation-reduction process | regulation of secretion | lipid catabolic process | organic substance metabolic process | animal organ development | negative regulation of cellular component movement | negative regulation of macrophage chemotaxis | uterus development | steroid metabolic process | regulation of cell communication | hormone metabolic process | prostate gland development | reproductive structure development | negative regulation of leukocyte migration | developmental process | regulation of transport | regulation of macrophage chemotaxis | positive regulation of lipid transport | cellular metabolic process | female sex differentiation | sex differentiation | oxidoreductase activity | aromatase activity | regulation of inflammatory response | negative regulation of locomotion | positive regulation of signaling | regulation of signaling | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | organelle | intracellular | membrane