QuickView for CYSLTR1;jsessionid=53D52DE55B9E5A7EE3FD1A04B920247C (gene)

Gene Symbol:

CYSLTR1 Homo sapiens

Full name:

cysteinyl leukotriene receptor 1

Synonyms:

CYSLT1, CYSLT1R, CYSLTR, HMTMF81, cysteinyl leukotriene receptor 1, G-protein coupled receptor HG55, LTD4 receptor, cysteinyl leukotriene D4 receptor

Genomic Location:

Chr X: 77414786-77469743

Description:

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smoot...

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This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACWWCAANK_UNKNOWN ,  RYTTCCTG_ETS2_B ,  TATAAA_TATA_01 ,  GGATTA_PITX2_Q2 ,  TEF_Q6 ,  TGACAGNY_MEIS1_01

Cytogenetic Map:

Xq21.1

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