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QuickView for Cardif (gene)


Gene Symbol:
MAVS Homo sapiens Homo sapiens
Full name:
mitochondrial antiviral signaling protein
Synonyms:
CARDIF, IPS-1, IPS1, VISA, mitochondrial antiviral-signaling protein, CARD adapter inducing interferon beta, CARD adaptor inducing IFN-beta, IFN-B promoter stimulator 1, interferon beta promoter stimulator protein 1, putative NF-kappa-B-activating protein 031N, virus-induced signaling adaptor, virus-induced-signaling adapter
Genomic Location:
Chr 20: 3775484-3795973
Description:
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 20
20p13





GO Molecular Function

kinase binding | protein kinase binding | enzyme binding | CARD domain binding | signaling adaptor activity | protein domain specific binding | molecular adaptor activity | protein binding

GO Biological Process

positive regulation of immune response | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | response to virus | regulation of cellular localization | negative regulation of type I interferon production | regulation of localization | positive regulation of IP-10 production | positive regulation of DNA-binding transcription factor activity | defense response to other organism | regulation of immune system process | regulation of protein import | defense response | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of protein secretion | positive regulation of cellular biosynthetic process | cellular process | response to exogenous dsRNA | negative regulation of viral life cycle | regulation of response to cytokine stimulus | positive regulation of defense response to virus by host | regulation of defense response to virus | positive regulation of nitrogen compound metabolic process | interspecies interaction between organisms | regulation of interferon-beta production | positive regulation of interleukin-8 production | regulation of immune response | regulation of cellular process | regulation of metabolic process | positive regulation of cellular protein metabolic process | positive regulation of tumor necrosis factor production | positive regulation of chemokine (C-C motif) ligand 5 production | positive regulation of type I interferon-mediated signaling pathway | regulation of peptide secretion | regulation of type I interferon production | response to stimulus | regulation of cellular protein localization | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | response to stress | positive regulation of cellular protein localization | activation of innate immune response | positive regulation of cytokine secretion | negative regulation of viral genome replication | cellular response to organic cyclic compound | regulation of protein transport | positive regulation of RNA biosynthetic process | regulation of peptide transport | regulation of intracellular transport | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | positive regulation of response to cytokine stimulus | response to nitrogen compound | signaling adaptor activity | response to external biotic stimulus | regulation of signal transduction | positive regulation of tumor necrosis factor secretion | response to dsRNA | regulation of phosphorylation | regulation of gene expression | positive regulation of secretion | positive regulation of intracellular protein transport | negative regulation of cytokine production | regulation of protein import into nucleus, translocation | positive regulation of cellular metabolic process | defense response to virus | positive regulation of protein phosphorylation | cellular response to exogenous dsRNA | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | positive regulation of interferon-beta secretion | negative regulation of viral process | positive regulation of protein localization to nucleus | regulation of cellular protein metabolic process | positive regulation of chemokine production | regulation of tumor necrosis factor production | response to bacterium | regulation of peroxisome organization | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | cellular response to dsRNA | defense response to bacterium | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | regulation of RNA metabolic process | positive regulation of transport | viral process | regulation of viral process | positive regulation of interferon-alpha production | positive regulation of molecular function | regulation of nucleocytoplasmic transport | regulation of cytokine secretion | activation of immune response | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | regulation of protein import into nucleus | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | regulation of RNA biosynthetic process | regulation of secretion | positive regulation of interleukin-6 production | immune response | regulation of type I interferon-mediated signaling pathway | regulation of protein secretion | regulation of tumor necrosis factor secretion | regulation of phosphate metabolic process | positive regulation of cytokine production | positive regulation of intracellular transport | positive regulation of protein transport | positive regulation of cytokine-mediated signaling pathway | positive regulation of protein import into nucleus, translocation | regulation of cell communication | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | positive regulation of interferon-alpha secretion | positive regulation of phosphorylation | regulation of cytokine production | positive regulation of protein import into nucleus | response to biotic stimulus | positive regulation of protein import | regulation of chemokine production | regulation of transport | positive regulation of transcription, DNA-templated | innate immune response | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | regulation of defense response to virus by host | positive regulation of metabolic process | immune system process | regulation of viral genome replication | cellular response to organic substance | regulation of protein localization | positive regulation of type I interferon production | regulation of viral life cycle | regulation of interleukin-6 production | positive regulation of nucleocytoplasmic transport | regulation of I-kappaB kinase/NF-kappaB signaling | regulation of cellular component organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | positive regulation of interleukin-6 secretion | positive regulation of interferon-beta production | regulation of phosphorus metabolic process

GO Cellular Component

peroxisomal membrane | integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | peroxisome | cell | organelle outer membrane | intrinsic component of membrane | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | organelle | mitochondrial outer membrane | mitochondrial envelope | outer membrane | mitochondrial membrane | intracellular | membrane