QuickView for Casp4 (gene)

Gene Symbol:

CASP4 Homo sapiens

Full name:

caspase 4

Synonyms:

ICE(rel)II, ICEREL-II, ICH-2, Mih1, Mih1/TX, TX, caspase-4, CASP-4, ICE and Ced-3 homolog 2, ICE(rel)-II, apoptotic cysteine protease Mih1/TX, caspase 4, apoptosis-related cysteine peptidase, caspase 4, apoptosis-related cysteine protease, protease ICH-2, protease TX

Genomic Location:

Chr 11: 104318804-104344535

Description:

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic proce...

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This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATATGCA_MIR448

Cytogenetic Map:

11q22.3

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