QuickView for Cdc2 Kinase (gene)
- Gene Symbol:
- CDK1
Homo sapiens - Full name:
- cyclin dependent kinase 1
- Synonyms:
- CDC2, CDC28A, P34CDC2, cyclin-dependent kinase 1, cell cycle controller CDC2, cell division control protein 2 homolog, cell division cycle 2, G1 to S and G2 to M, cell division protein kinase 1, p34 protein kinase
- Genomic Location:
- Chr 10: 62205690-62223930
- Description:
-
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and functio...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
GATTGGY_NFY_Q6_01 , E2F1_Q4_01 , E2F4DP1_01 , CTTTGA_LEF1_Q2 , TCF4_Q5 , LEF1_Q2 , E2F_Q6 , E2F_Q4 , GGGCGGR_SP1_Q6 , E2F1DP2_01
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
10q21.2
| Transcripts Names |
|---|
| NM_001786 |
| NM_033379 |
| NM_001130829 |
| NM_001170406 |
| NM_001170407 |
| NM_001320918 |
| XM_005270303 |
GO Molecular Function
cyclin binding | ribonucleotide binding | nucleotide binding | cyclin-dependent protein kinase activity | carbohydrate derivative binding | protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity | catalytic activity | chromatin binding | ATP binding | Hsp70 protein binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | histone kinase activity | cyclin-dependent protein serine/threonine kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | virus receptor activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heat shock protein binding | heterocyclic compound binding | small molecule binding
GO Biological Process
protein modification by small protein removal | nucleus organization | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | cell motility | regulation of neurogenesis | regulation of cellular localization | muscle tissue development | positive regulation of ATP metabolic process | intracellular signal transduction | proteolysis | regulation of cell development | regulation of localization | regulation of cell cycle G1/S phase transition | organelle fusion | positive regulation of striated muscle tissue development | regulation of programmed cell death | peptidyl-amino acid modification | positive regulation of G2/M transition of mitotic cell cycle | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | response to metal ion | histone modification | microtubule cytoskeleton organization | regulation of heart growth | regulation of protein import | cell differentiation | striated muscle cell development | nervous system development | response to drug | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | neurogenesis | positive regulation of phosphate metabolic process | regulation of DNA replication | generation of neurons | cardiac cell development | membrane organization | response to antibiotic | microtubule-based process | regulation of cardiac muscle cell proliferation | positive regulation of oxidative phosphorylation | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | localization | proteolysis involved in cellular protein catabolic process | chromatin organization | mitotic DNA integrity checkpoint | protein localization to kinetochore | karyogamy | negative regulation of G1/S transition of mitotic cell cycle | regulation of embryonic development | regulation of striated muscle tissue development | positive regulation of protein kinase activity | macromolecule localization | negative regulation of apoptotic process | endomembrane system organization | microtubule organizing center organization | membrane docking | regulation of cell cycle | positive regulation of catalytic activity | membrane disassembly | positive regulation of nitrogen compound metabolic process | response to inorganic substance | tissue development | regulation of cell differentiation | interspecies interaction between organisms | regulation of oxidative phosphorylation | muscle structure development | muscle cell differentiation | regeneration | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | organelle localization | positive regulation of cell cycle phase transition | ventricular cardiac muscle cell development | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | epithelium development | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | regulation of G2/M transition of mitotic cell cycle | cellular component organization | entry into host cell | protein deubiquitination | Golgi inheritance | viral life cycle | response to stimulus | peptidyl-threonine phosphorylation | regulation of Schwann cell differentiation | regulation of mitochondrial ATP synthesis coupled electron transport | cyclin-dependent protein kinase activity | muscle cell development | regulation of cellular protein localization | regulation of mitotic cell cycle phase transition | positive regulation of protein metabolic process | response to stress | negative regulation of G2/M transition of mitotic cell cycle | positive regulation of cellular protein localization | regulation of cell proliferation | mitotic G2 DNA damage checkpoint | anaphase-promoting complex-dependent catabolic process | cardiac muscle tissue development | regulation of cell cycle phase transition | mitotic nuclear envelope disassembly | protein serine/threonine kinase activity | programmed cell death | reproduction | cellular protein catabolic process | cellular localization | response to alcohol | cellular nitrogen compound metabolic process | cellular response to toxic substance | proteasomal protein catabolic process | nuclear envelope organization | regulation of protein transport | positive regulation of protein serine/threonine kinase activity | cellular component assembly | protein modification process | RNA polymerase II CTD heptapeptide repeat kinase activity | regulation of peptide transport | cellular biosynthetic process | macromolecule modification | activation of protein kinase activity | regulation of intracellular transport | ciliary basal body-plasma membrane docking | DNA repair | response to ethanol | locomotion | response to nitrogen compound | apoptotic process | organelle assembly | regulation of cell cycle G2/M phase transition | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | DNA damage response, signal transduction by p53 class mediator | cellular response to antibiotic | mitotic DNA damage checkpoint | multicellular organism development | negative regulation of cell cycle G2/M phase transition | response to activity | cell migration | positive regulation of DNA replication | regulation of MAPK cascade | phosphorus metabolic process | cellular response to DNA damage stimulus | positive regulation of muscle organ development | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | cellular response to oxidative stress | regulation of phosphorylation | positive regulation of cell cycle | positive regulation of mitotic cell cycle | signal transduction in response to DNA damage | regulation of gene expression | viral entry into host cell | cellular response to stress | cell cycle | protein catabolic process | chromosome condensation | positive regulation of intracellular protein transport | cell projection assembly | regulation of protein import into nucleus, translocation | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | response to axon injury | regulation of protein localization to nucleus | pronuclear fusion | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | cardiocyte differentiation | positive regulation of cell cycle G2/M phase transition | response to oxidative stress | protein localization to organelle | Golgi disassembly | positive regulation of cellular respiration | cell proliferation | positive regulation of protein localization to nucleus | biosynthetic process | response to cadmium ion | positive regulation of cardiac muscle cell proliferation | cell division | regulation of cellular protein metabolic process | cardiac muscle cell development | G2/M transition of mitotic cell cycle | fertilization | phosphorylation | response to toxic substance | signal transduction involved in cell cycle checkpoint | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | cellular response to drug | mitotic G1 DNA damage checkpoint | striated muscle tissue development | nuclear envelope disassembly | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | heart development | cell cycle G2/M phase transition | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | histone phosphorylation | positive regulation of transport | viral process | striated muscle cell differentiation | cell aging | single fertilization | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of mitotic cell cycle | organelle disassembly | positive regulation of molecular function | regulation of nucleocytoplasmic transport | positive regulation of cell cycle arrest | mitotic G2/M transition checkpoint | activation of MAPK activity | protein-containing complex assembly | positive regulation of organ growth | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of cardiac muscle tissue development | G1 DNA damage checkpoint | regulation of protein import into nucleus | centrosome cycle | histone kinase activity | regulation of cellular respiration | Golgi organization | protein localization to chromosome, centromeric region | regulation of kinase activity | response to wounding | DNA metabolic process | cyclin-dependent protein serine/threonine kinase activity | regulation of intracellular signal transduction | cellular macromolecule catabolic process | anatomical structure development | response to amine | positive regulation of mitotic cell cycle phase transition | mitotic cell cycle | cell projection organization | metabolic process | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | cellular protein localization | cellular response to hydrogen peroxide | nucleobase-containing compound metabolic process | protein kinase activity | cellular response to reactive oxygen species | organic substance metabolic process | response to copper ion | cell death | virus receptor activity | animal organ development | response to reactive oxygen species | cilium assembly | signal transduction involved in mitotic cell cycle checkpoint | positive regulation of kinase activity | protein modification by small protein conjugation or removal | regulation of ATP metabolic process | regulation of phosphate metabolic process | DNA packaging | cytoskeleton organization | positive regulation of muscle tissue development | positive regulation of intracellular transport | positive regulation of MAPK cascade | positive regulation of protein transport | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | cilium organization | organonitrogen compound catabolic process | cardiac muscle cell differentiation | regulation of glial cell differentiation | positive regulation of protein import into nucleus, translocation | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | regulation of gliogenesis | positive regulation of developmental growth | signaling | covalent chromatin modification | positive regulation of growth | response to organic cyclic compound | cell development | regulation of developmental growth | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | cellular macromolecule localization | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | positive regulation of protein import into nucleus | regulation of organ growth | signal transduction involved in DNA damage checkpoint | regulation of nervous system development | regulation of developmental process | positive regulation of DNA metabolic process | kinase activity | organelle inheritance | developmental process | organelle organization | positive regulation of protein import | positive regulation of cell cycle process | peptidyl-serine phosphorylation | cellular protein modification process | mitotic G1/S transition checkpoint | regulation of transport | positive regulation of heart growth | DNA conformation change | response to organonitrogen compound | cell cycle phase transition | ventricular cardiac muscle cell differentiation | epithelial cell differentiation | heterocycle metabolic process | signal transduction involved in mitotic G1 DNA damage checkpoint | regulation of generation of precursor metabolites and energy | positive regulation of metabolic process | chromosome organization | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | regulation of protein localization | regulation of cell death | positive regulation of cardiac muscle tissue development | modification-dependent protein catabolic process | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | DNA replication | negative regulation of cell death | circulatory system development | aging | positive regulation of nucleocytoplasmic transport | sexual reproduction | positive regulation of signaling | protein localization to chromosome | signal transduction | regulation of signaling | animal organ regeneration | positive regulation of gene expression | regulation of muscle organ development | macromolecule metabolic process | positive regulation of mitochondrial ATP synthesis coupled electron transport | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | cyclin B1-CDK1 complex | mitochondrial matrix | chromosome | intracellular membrane-bounded organelle | catalytic complex | microtubule organizing center | protein kinase complex | cell | nuclear lumen | microtubule | cytoplasm | spindle | intracellular organelle | endoplasmic reticulum | centrosome | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | nucleoplasm | midbody | nuclear chromosome | vesicle | transferase complex | extracellular exosome | microtubule cytoskeleton | mitochondrion | chromosome, telomeric region | spindle microtubule | extracellular region | serine/threonine protein kinase complex | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | cyclin-dependent protein kinase holoenzyme complex | cytosol | cytoskeleton | nuclear chromosome, telomeric region | intracellular | mitotic spindle | membrane | supramolecular complex
