QuickView for Chsy1 (gene)

Gene Symbol:

CHSY1 Homo sapiens

Full name:

chondroitin sulfate synthase 1

Synonyms:

CHSY, CSS1, ChSy-1, TPBS, chondroitin sulfate synthase 1, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1, N-acetylgalactosaminyltransferase II, carbohydrate synthase 1, chondroitin glucuronyltransferase 1, chondroitin glucuronyltransferase II, chondroitin synthase 1, glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1

Genomic Location:

Chr 15: 99533455-99609649

Description:

This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. ...

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This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAG_MIR518A2 ,  AAGCCAT_MIR135A_MIR135B ,  OSF2_Q6 ,  TTGGAGA_MIR5155P_MIR519E ,  CAGGTA_AREB6_01 ,  TGCCTTA_MIR124A ,  AP2_Q3 ,  GTGCCTT_MIR506 ,  CAAGGAT_MIR362 ,  TGGTGCT_MIR29A_MIR29B_MIR29C

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-362 ,  Predicted Gene Targets for miR-544

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miRNA binding sites
(Source: miRecords):

hsa-miR-1 Targeted Genes ,  hsa-miR-124 Targeted Genes

Cytogenetic Map:

15q26.3

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