QuickView for ClC-K2 (gene)

Gene Symbol:

CLCNKB Homo sapiens

Full name:

chloride voltage-gated channel Kb

Synonyms:

CLCKB, ClC-K2, ClC-Kb, chloride channel protein ClC-Kb, chloride channel, kidney, B, chloride channel, voltage-sensitive Kb

Genomic Location:

Chr 1: 16242834-16256390

Description:

The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt ...

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The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes

External Links:

Entrez Gene

Cytogenetic Map:

1p36.13

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