QuickView for Cldn12 (gene)

Gene Symbol:: CLDN12 Homo sapiens
Full name:: claudin 12
Synonyms:: claudin-12
Genomic Location:: Chr 7: 89870732-89883204
Description:: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintain...
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This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.
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Orthologs:: Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Bos taurus , Canis lupus familiaris , Gallus gallus , Danio rerio
External Links:: Entrez Gene

Transcription Factor Binding Sites:: GABP_B , RYTTCCTG_ETS2_B , YTATTTTNR_MEF2_02 , CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I , MGGAAGTG_GABP_B , AATGTGA_MIR23A_MIR23B , ER_Q6_02 , ER_Q6_01

miRNA binding sites (Source: TargetScan):: Predicted Gene Targets for let-7 , Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-23 , Predicted Gene Targets for miR-323 , Predicted Gene Targets for miR-381 , Predicted Gene Targets for miR-485-5p , Predicted Gene Targets for miR-503