QuickView for Cochlin (biogroup)

Description:: Cochlin is an extracellular matrix (ECM) protein highly abundant in the cochlea and vestibule of the inner ear, constituting the major non-collagen component of the ECM of the inner ear. The gene encoding cochlin is mutated in DFNA9, an hereditary hearing impairment disorder. Cochlin has been identified in the trabecular meshwork (TM) of glaucomatous patients, but not in healthy controls. The TM is a filter like area of tissue in the eye; cochlin may have a role in cell adhesion, mechanosensation, and modulation of the TM filter. It is also expressed in follicular dendritic cells in spleen and lymph nodes. Here, cochlin is cleaved by aggrecanases and secreted into blood circulation during inflammation, contributing to the antibacterial innate immune response.

1 feature

Symbol	EntrezGene ID
COCH	1690