QuickView for Col3A1 (gene)

Gene Symbol:

COL3A1 Homo sapiens

Full name:

collagen type III alpha 1 chain

Synonyms:

EDS4A, EDSVASC, collagen alpha-1(III) chain, Ehlers-Danlos syndrome type IV, autosomal dominant, alpha-1 type III collagen, alpha1 (III) collagen, collagen, fetal, collagen, type III, alpha 1

Genomic Location:

Chr 2: 189547344-189585717

Description:

This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneu...

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This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTGTAT_MIR381 ,  CACTGTG_MIR128A_MIR128B ,  NFAT_Q6 ,  CIZ_01 ,  YATTNATC_UNKNOWN ,  CREB_Q3 ,  RP58_01 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  ATTCTTT_MIR186 ,  ACTACCT_MIR196A_MIR196B ,  WWTAAGGC_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  FOXM1_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  CEBPGAMMA_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-380-5p

miRNA binding sites
(Source: miRecords):

hsa-miR-29c Targeted Genes

Cytogenetic Map:

2q32.2

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