Correlation Engine 2.0
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QuickView for Complement factor B (gene)

Gene Symbol:
CFB Homo sapiens Homo sapiens
Full name:
complement factor B
AHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2, complement factor B, B-factor, properdin, C3 proaccelerator, C3 proactivator, C3/C5 convertase, glycine-rich beta-glycoprotein, properdin factor B
Genomic Location:
Chr 6: 32021752-32027839
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine pr...
Mus musculus Rattus norvegicus Canis lupus familiaris Pan troglodytes Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 6

GO Molecular Function

complement binding | hydrolase activity | catalytic activity | serine hydrolase activity | protein binding | serine-type endopeptidase activity | serine-type peptidase activity | endopeptidase activity | peptidase activity

GO Biological Process

positive regulation of immune response | proteolysis | complement activation | regulation of immune system process | defense response | regulation of proteolysis | regulation of immune response | regulation of metabolic process | response to stimulus | positive regulation of immune system process | response to stress | regulation of humoral immune response | regulation of protein processing | nitrogen compound metabolic process | regulation of acute inflammatory response | regulation of gene expression | complement activation, alternative pathway | regulation of nitrogen compound metabolic process | protein activation cascade | regulation of complement activation | humoral immune response | regulation of protein metabolic process | activation of immune response | protein metabolic process | metabolic process | immune response | organic substance metabolic process | serine-type endopeptidase activity | serine-type peptidase activity | endopeptidase activity | innate immune response | immune system process | peptidase activity | regulation of inflammatory response | macromolecule metabolic process

GO Cellular Component

cell | plasma membrane | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | blood microparticle | membrane