QuickView for Cry2 (gene)

Gene Symbol:

CRY2 Homo sapiens

Full name:

cryptochrome circadian regulator 2

Synonyms:

HCRY2, PHLL2, cryptochrome-2, cryptochrome 2 (photolyase-like), cryptochrome circadian clock 2, growth-inhibiting protein 37

Genomic Location:

Chr 11: 45825605-45861372

Description:

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in ...

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This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ARNT_01 ,  AAAYWAACM_HFH4_01 ,  NGFIC_01 ,  SRY_01 ,  DBP_Q6 ,  GTGACGY_E4F1_Q6 ,  CCTGTGA_MIR513 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  GTCTTCC_MIR7 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GGGCGGR_SP1_Q6 ,  E4F1_Q6 ,  TGTTTGY_HNF3_Q6 ,  GATA1_02 ,  CCTGCTG_MIR214 ,  TTGTTT_FOXO4_01 ,  HNF4_01_B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-378* ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-7

Cytogenetic Map:

11p11.2

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