Bookmark
Forward
QuickView for Crystal violet (compound)
PubChem
| Name: | Gentian Violet |
|---|---|
| PubChem Compound ID: | 11057 |
| Description: | A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties. |
| Molecular formula: | C25H30ClN3 |
| Molecular weight: | 407.979 g/mol |
| Synonyms: |
Methylrosanilini chloridum; Crystal Violet 10B; Crystal Violet 6BO; Gentianaviolett [German]; Badil; Crystal Violet Extra Pure; Crystal Violet FN; Violet 5BO; Meroxylan; Aizen Crystal Violet Extra Pure.
show more » |
DrugBank
Identification
| Name: | Gentian Violet |
|---|---|
| Name (isomeric): | DB00406 |
| Drug Type: | small molecule |
| Description: | A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties. |
| Synonyms: |
Crystal Violet
|
| Brand: | Hidaco crystal Violet, Meroxylan-Wander, Plastoresin Violet 5BO, Oxycolor, C.I. Basic Violet 3, Violet 5BO, Methyl Violet 10BNS, Brilliant Violet 5B, Genticid, Crystal Violet AON, Gentioletten, Hexamethyl Violet, Paper Blue R, Bismuth Violet, Crystal Violet chloride, Crystal Violet O, Violet XXIII, Violet 6BN, Crystal Violet Technical, Methyl Violet 5BO, crystal violet for microscopy, Violet CP, Crystal Violet USP, Crystal Violet BPC, Crystal Violet HL2, Oxyozyl, Crystal Violet SS, Crystal Violet chloride salt, Methyl Violet 10BK, Methyl Violet 6B, Methyl Violet 10BN, Methyl Violet 10BO, Axuris, Atmonil, methylrosanilinium chloride, Calcozine Violet C, Methyl Violet 10BD, Crystal Violet Pure DSC, Avermin, Mitsui Crystal Violet, Gentersal, GV-Eleven, Pyoktanin, Hexamethylpararosaniline chloride, Crystal Violet Extra Pure APN, Vianin, Adergon, Crystal Violet 5BO, Aizen Crystal Violet Extra Pure, Basic Violet 3, Genapax, gention violet alchoholic staining solution, gentian violet gr, Vermicid, Methyl Violet 5BNO, Badil, Aniline Violet, Crystal Violet BP, Oxiuran, Methylrosaniline chloride, Aniline Violet pyoktanine, Crystal Violet 6BO, Hidaco Brilliant Crystal Violet, Basic Violet BN, Crystal Violet base, Methyl violet, Viocid, Meroxyl-Wander, Hecto Violet R, Aizen Crystal Violet, Methyl Violet 10B, Crystal Violet 6B, Crystal Violet 10B, Calcozine Violet 6BN, Crystal Violet Extra Pure APNX, Gvs, Gentiaverm, Crystal Violet Extra Pure, Hectograph Violet SR, Basic Violet-3, Crystal Violet AO, Crystal Violet FN, Crystal Violet Pure DSC Brilliant |
| Brand name mixture: | Pinkeye Spray(Gentian Violet + Neomycin (Neomycin Sulfate)), Blu Kote Dr Naylors(Acriflavine + Gentian Violet + Glycerine + Isopropyl Alcohol + Sodium Propionate + Urea), Wound Kote Gentian Violet Spray Wound Dre(Acriflavine + Furfural + Methyl Violet + Sodium Propionate + Urea), Pink Eye Spray(Furfural + Gentian Violet + Isopropyl Alcohol + Met... show more » |
| Category: | Anti-Infective Agents, Local |
| CAS number: | 14426-25-6 |
Pharmacology
| Indication: | For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive). |
|---|---|
| Pharmacology: |
Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease...
show more » |
| Mechanism of Action: |
In aqueous solutions Gentian violet (GV) dissociates into positive (GV+)and negative ions (Cl-) that penetrate through the wall and membrane of both gram-positive and gram-negative bacterial cells. The GV+ interacts with negatively charged components of bacterial cells including the lipopolysaccharide (on the cell wall), the peptidoglycan and DNA. ...
show more » |
| Biotransformation: | Primarily hepatic, mostly demethylation |
| Toxicity: | LD50=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count. |
| Affected organisms: | Yeast and other fungi||Bacteria and protozoa |
Targets
Transporters
