QuickView for D9S411E (gene)

Gene Symbol:

APBA1 Homo sapiens

Full name:

amyloid beta precursor protein binding family A member 1

Synonyms:

D9S411E, LIN10, MINT1, X11, X11A, X11ALPHA, amyloid-beta A4 precursor protein-binding family A member 1, amyloid beta A4 precursor protein-binding family A member 1, adapter protein X11alpha, adaptor protein X11alpha, amyloid beta (A4) precursor protein-binding, family A, member 1 (X11), mint-1, neuron-specific X11 protein, neuronal munc18-1-interacting protein 1, phosphotyrosine-binding/-interacting domain (PTB)-bearing protein

Genomic Location:

Chr 9: 71235022-71477042

Description:

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. Thi...

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The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TGIF_01 ,  MAZR_01 ,  GR_Q6_01 ,  STAT_Q6 ,  SOX9_B1 ,  STAT5B_01 ,  CAGGTG_E12_Q6 ,  ETS2_B ,  RRAGTTGT_UNKNOWN ,  YKACATTT_UNKNOWN ,  CCCNNGGGAR_OLF1_01 ,  YTTCCNNNGGAMR_UNKNOWN ,  AAGWWRNYGGC_UNKNOWN ,  STAT3_01 ,  SOX5_01 ,  GATA1_02 ,  NRF2_Q4 ,  PTF1BETA_Q6 ,  YCATTAA_UNKNOWN ,  STAT_01 ,  TCTCTCC_MIR185 ,  RNGTGGGC_UNKNOWN ,  AP2_Q6 ,  TTGTTT_FOXO4_01 ,  IK3_01 ,  IK1_01 ,  CTGAGCC_MIR24 ,  TTCYNRGAA_STAT5B_01 ,  CREL_01 ,  TGACAGNY_MEIS1_01 ,  STAT1_01 ,  STAT5A_01 ,  CAGCTG_AP4_Q5 ,  SRY_02 ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  TGACATY_UNKNOWN ,  ETS1_B ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-24

Cytogenetic Map:

9q21.12

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