QuickView for DAB2;jsessionid=C334B788719D2D1F44904F62090B5B24 (gene)

Gene Symbol:

DAB2 Homo sapiens

Full name:

DAB2, clathrin adaptor protein

Synonyms:

DOC-2, DOC2, disabled homolog 2, Dab, mitogen-responsive phosphoprotein, homolog 2, adaptor molecule disabled-2, differentially expressed in ovarian carcinoma 2, differentially-expressed protein 2, disabled homolog 2, mitogen-responsive phosphoprotein

Genomic Location:

Chr 5: 39407537-39461092

Description:

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide...

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This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  HNF1_01 ,  FXR_IR1_Q6 ,  OSF2_Q6 ,  CAGCTTT_MIR320 ,  LMO2COM_02 ,  RACCACAR_AML_Q6 ,  AR_Q2 ,  RORA2_01 ,  ER_Q6_02 ,  HNF6_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-149

Cytogenetic Map:

5p13.1

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