QuickView for DARS2 (gene)
- Gene Symbol:
- DARS2
Homo sapiens - Full name:
- aspartyl-tRNA synthetase 2, mitochondrial
- Synonyms:
- ASPRS, LBSL, MT-ASPRS, aspartate--tRNA ligase, mitochondrial, aspartate tRNA ligase 2, mitochondrial, aspartyl-tRNA synthetase, mitochondrial
- Genomic Location:
- Chr 1: 172060581-172094305
- Description:
-
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL).
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
1q25.1
GO Molecular Function
aspartate-tRNA ligase activity | nucleic acid binding | ribonucleotide binding | tRNA binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | aminoacyl-tRNA ligase activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | protein dimerization activity | ligase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | aspartate-tRNA(Asn) ligase activity | heterocyclic compound binding | small molecule binding | RNA binding
GO Biological Process
RNA metabolic process | tRNA aminoacylation | mitochondrial asparaginyl-tRNA aminoacylation | cellular process | cellular amino acid metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | peptide biosynthetic process | mitochondrial translation | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | cellular biosynthetic process | nitrogen compound metabolic process | small molecule metabolic process | cellular amide metabolic process | tRNA aminoacylation for protein translation | translation | tRNA aminoacylation for mitochondrial protein translation | biosynthetic process | peptide metabolic process | carboxylic acid metabolic process | tRNA metabolic process | protein metabolic process | metabolic process | mitochondrial gene expression | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | amide biosynthetic process | asparaginyl-tRNA aminoacylation | organic acid metabolic process | cellular protein metabolic process | cellular macromolecule biosynthetic process | ncRNA metabolic process | heterocycle metabolic process | cellular metabolic process | mitochondrial RNA metabolic process | macromolecule metabolic process
GO Cellular Component
mitochondrial matrix | intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
