Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for DDAH2;jsessionid=2E32F42FB55C9FDE0939DAC76A30B869 (gene)


Gene Symbol:
DDAH2 Homo sapiens Homo sapiens
Full name:
dimethylarginine dimethylaminohydrolase 2
Synonyms:
DDAH, DDAHII, G6a, HEL-S-277, NG30, N(G),N(G)-dimethylarginine dimethylaminohydrolase 2, S-phase protein, dimethylargininase-2, dimethylarginine dimethylaminohydrolase II, epididymis secretory protein Li 277, testis tissue sperm-binding protein Li 54e
Genomic Location:
Chr 6: 31802796-31806018
Description:
This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Canis lupus familiaris Bos taurus Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 6
6p21.33





GO Molecular Function

carboxylic acid binding | hydrolase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines | catalytic activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | anion binding | amino acid binding | ion binding | protein binding | dimethylargininase activity | organic acid binding | small molecule binding

GO Biological Process

intracellular signal transduction | regulation of programmed cell death | nitric oxide biosynthetic process | regulation of nitric oxide biosynthetic process | negative regulation of cellular process | reactive oxygen species metabolic process | positive regulation of cellular biosynthetic process | cellular amino acid catabolic process | cellular process | organic substance catabolic process | positive regulation of reactive oxygen species metabolic process | negative regulation of apoptotic process | positive regulation of nitrogen compound metabolic process | cellular amino acid metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | response to stimulus | positive regulation of nitric oxide metabolic process | carboxylic acid catabolic process | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | reactive oxygen species biosynthetic process | cellular biosynthetic process | regulation of neurotransmitter levels | positive regulation of reactive oxygen species biosynthetic process | nitrogen compound metabolic process | regulation of catalytic activity | regulation of nitric-oxide synthase activity | nitric oxide mediated signal transduction | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | second-messenger-mediated signaling | neurotransmitter metabolic process | biosynthetic process | cell communication | regulation of cellular metabolic process | arginine catabolic process | drug metabolic process | carboxylic acid metabolic process | reactive nitrogen species metabolic process | metabolic process | negative regulation of programmed cell death | organic substance metabolic process | regulation of reactive oxygen species biosynthetic process | organonitrogen compound catabolic process | neurotransmitter biosynthetic process | arginine metabolic process | signaling | regulation of oxidoreductase activity | organic acid metabolic process | nitric oxide metabolic process | regulation of reactive oxygen species metabolic process | citrulline metabolic process | positive regulation of nitric oxide biosynthetic process | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | negative regulation of cell death | signal transduction

GO Cellular Component

intracellular membrane-bounded organelle | microtubule organizing center | cell | cytoplasm | intracellular organelle | vesicle | extracellular exosome | microtubule cytoskeleton | mitochondrion | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cytosol | cytoskeleton | intracellular