QuickView for DENND1A;jsessionid=4D9EF5A5CB76A48702A9395011A7DC07 (gene)

Gene Symbol:

DENND1A Homo sapiens

Full name:

DENN domain containing 1A

Synonyms:

FAM31A, KIAA1608, DENN domain-containing protein 1A, DENN/MADD domain containing 1A, connecdenn 1

Genomic Location:

Chr 9: 125181754-125732238

Description:

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). T...

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Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  TTGCACT_MIR130A_MIR301_MIR130B ,  CACCAGC_MIR138 ,  ACCAAAG_MIR9

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-137

Cytogenetic Map:

9q33.3

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