QuickView for DHODH (gene)
- Gene Symbol:
- DHODH
Homo sapiens - Full name:
- dihydroorotate dehydrogenase (quinone)
- Synonyms:
- DHOdehase, POADS, URA1, dihydroorotate dehydrogenase (quinone), mitochondrial, dihydroorotate oxidase, human complement of yeast URA1
- Genomic Location:
- Chr 16: 70600144-70616456
- Description:
-
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Pan troglodytes , Danio rerio , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
16q22.2
GO Molecular Function
cofactor binding | ribonucleotide binding | FMN binding | nucleotide binding | coenzyme binding | carbohydrate derivative binding | catalytic activity | dihydroorotate dehydrogenase activity | anion binding | ion binding | ubiquinone binding | organic cyclic compound binding | quinone binding | drug binding | heterocyclic compound binding | oxidoreductase activity, acting on the CH-CH group of donors | oxidoreductase activity | small molecule binding
GO Biological Process
pyrimidine nucleoside biosynthetic process | response to extracellular stimulus | response to nutrient levels | positive regulation of apoptotic process | pyrimidine nucleoside metabolic process | regulation of programmed cell death | regulation of mitochondrial fission | establishment of localization | response to drug | regulation of organelle organization | response to L-arginine | cellular process | secretion | localization | nucleotide metabolic process | female pregnancy | ribose phosphate metabolic process | ribonucleotide metabolic process | regulation of cellular process | regulation of apoptotic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to stimulus | response to stress | pyrimidine nucleotide metabolic process | cellular nitrogen compound biosynthetic process | response to starvation | reproduction | cellular nitrogen compound metabolic process | carbohydrate derivative biosynthetic process | cellular biosynthetic process | nucleotide biosynthetic process | response to nitrogen compound | system development | nitrogen compound metabolic process | reproductive process | multicellular organism development | phosphorus metabolic process | response to amino acid | response to purine-containing compound | ribonucleoside monophosphate biosynthetic process | mammary gland development | dihydroorotate dehydrogenase activity | organophosphate metabolic process | nucleoside metabolic process | small molecule metabolic process | response to nutrient | pyrimidine nucleotide biosynthetic process | nucleobase-containing small molecule metabolic process | biosynthetic process | aromatic compound biosynthetic process | response to xenobiotic stimulus | pyrimidine nucleobase biosynthetic process | pyrimidine ribonucleoside biosynthetic process | phosphate-containing compound metabolic process | regulation of mitochondrion organization | response to organic substance | gland development | lactation | UMP biosynthetic process | anatomical structure development | 'de novo' pyrimidine nucleobase biosynthetic process | metabolic process | regulation of body fluid levels | oxidation-reduction process | pyrimidine ribonucleotide biosynthetic process | positive regulation of cell death | body fluid secretion | nucleobase-containing compound metabolic process | response to caffeine | organic substance metabolic process | animal organ development | positive regulation of programmed cell death | response to alkaloid | pyrimidine nucleobase metabolic process | response to organic cyclic compound | ribose phosphate biosynthetic process | regulation of developmental process | developmental process | carbohydrate derivative metabolic process | 'de novo' UMP biosynthetic process | response to organonitrogen compound | heterocycle metabolic process | oxidoreductase activity, acting on the CH-CH group of donors | cellular metabolic process | regulation of cell death | oxidoreductase activity | regulation of cellular component organization | nucleoside monophosphate biosynthetic process | multicellular organismal process
GO Cellular Component
integral component of membrane | organelle inner membrane | intracellular membrane-bounded organelle | mitochondrial inner membrane | somatodendritic compartment | organelle membrane | cell body | cell | nuclear lumen | neuronal cell body | intrinsic component of membrane | cytoplasm | intracellular organelle | nucleoplasm | plasma membrane | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | cell periphery | membrane-enclosed lumen | mitochondrial membrane | cytosol | intracellular | membrane
