QuickView for DIO2 (gene)

Gene Symbol:

DIO2 Homo sapiens

Full name:

iodothyronine deiodinase 2

Synonyms:

5DII, D2, DIOII, SelY, TXDI2, type II iodothyronine deiodinase, deiodinase, iodothyronine type II, deiodinase-2, deiodonase-2, thyroxine deiodinase, type II, type 2 DI, type 2 iodothyronine deiodinase, type-II 5'-deiodinase, type-II 5'deiodinase

Genomic Location:

Chr 14: 79733622-79748278

Description:

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, including in thyroid, placenta, pituitary and brain. It i...

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The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, including in thyroid, placenta, pituitary and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. It has also been reported to be highly expressed in thyroids of patients with Graves disease, and in follicular adenomas. The intrathyroidal T4 to T3 conversion by this enzyme may contribute significantly to the relative increase in thyroidal T3 production in these patients. This protein is a selenoprotein containing the rare selenocysteine (Sec) amino acid at its active site, and may contain additional Sec residues. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  IRF1_01 ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  GATA3_01 ,  GCAAGGA_MIR502 ,  HP1SITEFACTOR_Q6 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  ACTTTAT_MIR1425P ,  AAGCAAT_MIR137 ,  CREB_Q3 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  TATAAA_TATA_01 ,  CDPCR3HD_01 ,  CAGGTA_AREB6_01 ,  YYCATTCAWW_UNKNOWN ,  CAGGTG_E12_Q6 ,  TST1_01 ,  TATA_C ,  CTCAAGA_MIR526B ,  ACCAAAG_MIR9 ,  CDPCR1_01 ,  LMO2COM_02 ,  S8_01 ,  IRF_Q6 ,  POU1F1_Q6 ,  PAX8_B ,  AREB6_03 ,  YTAAYNGCT_UNKNOWN ,  IK3_01 ,  TATA_01 ,  CTGCAGY_UNKNOWN ,  TGACGTCA_ATF3_Q6 ,  GGCCAGT_MIR193A_MIR193B ,  TGACAGNY_MEIS1_01 ,  ICSBP_Q6 ,  CTTTGT_LEF1_Q2 ,  FOXM1_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  CREB_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-134 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-543 ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

14q31.1

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