QuickView for DLC1;jsessionid=E39EB45B997E20C6E7AEF5980CE26153 (gene)

Gene Symbol:

DLC1 Homo sapiens

Full name:

DLC1 Rho GTPase activating protein

Synonyms:

ARHGAP7, HP, STARD12, p122-RhoGAP, rho GTPase-activating protein 7, Rho-GTPase-activating protein 7, START domain-containing protein 12, StAR-related lipid transfer (START) domain containing 12, deleted in liver cancer 1 protein, deleted in liver cancer 1 variant 2, deleted in liver cancer variant 4, rho-type GTPase-activating protein 7

Genomic Location:

Chr 8: 12985243-13416766

Description:

This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of co...

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This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CTTGTAT_MIR381 ,  RTAAACA_FREAC2_01 ,  TTTGCAC_MIR19A_MIR19B ,  TTANTCA_UNKNOWN ,  RYTTCCTG_ETS2_B ,  CACGTG_MYC_Q2 ,  CATTGTYY_SOX9_B1 ,  STAT6_02 ,  NKX3A_01 ,  YATTNATC_UNKNOWN ,  CAGTGTT_MIR141_MIR200A ,  CTTTGA_LEF1_Q2 ,  TTF1_Q6 ,  NKX22_01 ,  GGTGAAG_MIR412 ,  TAAWWATAG_RSRFC4_Q2 ,  GGGAGGRR_MAZ_Q6 ,  OCT1_Q6 ,  SOX9_B1 ,  ATACCTC_MIR202 ,  ETS2_B ,  ATTCTTT_MIR186 ,  GTAAGAT_MIR200A ,  TGCTGAY_UNKNOWN ,  PITX2_Q2 ,  YKACATTT_UNKNOWN ,  OCT1_03 ,  RNGTGGGC_UNKNOWN ,  NMYC_01 ,  HAND1E47_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  YTAATTAA_LHX3_01 ,  RGAGGAARY_PU1_Q6 ,  CTGAGCC_MIR24 ,  CTGCAGY_UNKNOWN ,  AGGGCAG_MIR18A ,  CAGCTG_AP4_Q5 ,  YNGTTNNNATT_UNKNOWN ,  CRX_Q4 ,  ERR1_Q2 ,  ETS1_B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-485-3p ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

8p22

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