QuickView for DLG4 (gene)

Gene Symbol:

DLG4 Homo sapiens

Full name:

discs large MAGUK scaffold protein 4

Synonyms:

PSD95, SAP-90, SAP90, disks large homolog 4, Tax interaction protein 15, discs large homolog 4, post-synaptic density protein 95, synapse-associated protein 90

Genomic Location:

Chr 17: 7033933-7063781

Description:

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, an...

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This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  GATA1_03 ,  ACACTCC_MIR122A ,  TTTTGAG_MIR373 ,  TCCCRNNRTGC_UNKNOWN ,  ACATTCC_MIR1_MIR206 ,  GGATTA_PITX2_Q2 ,  BACH2_01 ,  ATGCTGC_MIR103_MIR107 ,  AP1_Q2_01 ,  PTF1BETA_Q6 ,  BACH1_01 ,  GAGCCAG_MIR149 ,  PPAR_DR1_Q2 ,  CRX_Q4 ,  CCACACA_MIR147

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-149

Cytogenetic Map:

17p13.1

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