QuickView for DNA polymerase gamma (gene)

Gene Symbol:

POLG Homo sapiens

Full name:

DNA polymerase gamma, catalytic subunit

Synonyms:

MDP1, MIRAS, MTDPS4A, MTDPS4B, PEO, POLG1, POLGA, SANDO, SCAE, DNA polymerase subunit gamma-1, PolG-alpha, mitochondrial DNA polymerase catalytic subunit, polymerase (DNA directed), gamma, polymerase (DNA) gamma, catalytic subunit, truncated mitochondrial DNA polymerase gamma catalytic subunit

Genomic Location:

Chr 15: 87660554-87679030

Description:

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progr...

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Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATGCAGT_MIR217 ,  TTANTCA_UNKNOWN ,  FOXJ2_02 ,  VDR_Q3 ,  MAF_Q6 ,  CEBPB_01 ,  ZID_01 ,  AHR_01 ,  SMAD_Q6 ,  HTF_01 ,  SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-370

Cytogenetic Map:

15q26.1

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