QuickView for DNAJB4;jsessionid=4BF39E7C5BE812240FC7064240DE1F7D (gene)
- Gene Symbol:
- DNAJB4
Homo sapiens - Full name:
- DnaJ heat shock protein family (Hsp40) member B4
- Synonyms:
- DNAJW, DjB4, HLJ1, dnaJ homolog subfamily B member 4, DnaJ (Hsp40) homolog, subfamily B, member 4, DnaJ-like heat shock protein 40, HSP40 homolog, heat shock 40 kDa protein 1 homolog, heat shock protein 40 homolog, human liver DnaJ-like protein
- Genomic Location:
- Chr 1: 78243224-78255586
- Description:
-
The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Gallus gallus , Danio rerio , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
1p31.1
GO Molecular Function
enzyme activator activity | unfolded protein binding | molecular function regulator | chaperone binding | protein binding | ATPase activator activity | enzyme regulator activity | ATPase regulator activity
GO Biological Process
positive regulation of ATPase activity | 'de novo' posttranslational protein folding | enzyme activator activity | negative regulation of cellular process | negative regulation of RNA biosynthetic process | cellular process | chaperone-mediated protein folding | negative regulation of nucleic acid-templated transcription | positive regulation of catalytic activity | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | response to topologically incorrect protein | response to stimulus | response to stress | regulation of ATPase activity | response to temperature stimulus | negative regulation of metabolic process | molecular function regulator | regulation of nucleic acid-templated transcription | regulation of catalytic activity | regulation of gene expression | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | positive regulation of hydrolase activity | 'de novo' protein folding | regulation of cellular metabolic process | regulation of RNA metabolic process | positive regulation of molecular function | ATPase activator activity | response to organic substance | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | protein folding | negative regulation of biosynthetic process | negative regulation of gene expression | response to heat | regulation of transcription, DNA-templated | enzyme regulator activity | response to unfolded protein | chaperone cofactor-dependent protein refolding | negative regulation of transcription by RNA polymerase II | ATPase regulator activity
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | plasma membrane | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | intracellular | membrane
