QuickView for DNMT3B (gene)

Gene Symbol:

DNMT3B Homo sapiens

Full name:

DNA methyltransferase 3 beta

Synonyms:

ICF, ICF1, M.HsaIIIB, DNA (cytosine-5)-methyltransferase 3B, DNA (cytosine-5-)-methyltransferase 3 beta, DNA MTase HsaIIIB, DNA cytosine-5--methyltransferase 3 beta, DNA methyltransferase HsaIIIB

Genomic Location:

Chr 20: 30813852-30860823

Description:

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance met...

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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  MZF1_01 ,  SREBP1_Q6 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  CATTTCA_MIR203 ,  CAGGTG_E12_Q6 ,  TTCYRGAA_UNKNOWN ,  NKX25_02 ,  CAGCAGG_MIR370 ,  AREB6_03 ,  SREBP_Q3 ,  CTTTGT_LEF1_Q2 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-29

miRNA binding sites
(Source: miRecords):

hsa-miR-148a Targeted Genes ,  hsa-miR-148b Targeted Genes ,  hsa-miR-29a Targeted Genes ,  hsa-miR-29b Targeted Genes ,  hsa-miR-29c Targeted Genes

Cytogenetic Map:

20q11.21

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