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QuickView for DPEP1 (gene)


Gene Symbol:
DPEP1 Homo sapiens Homo sapiens
Full name:
dipeptidase 1
Synonyms:
MBD1, MDP, RDP, dipeptidase 1, dehydropeptidase-I, dipeptidase 1 (renal), hRDP, microsomal dipeptidase, renal dipeptidase, testicular tissue protein Li 57
Genomic Location:
Chr 16: 88214501-88232338
Description:
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Schizosaccharomyces pombe Gallus gallus Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 16
16q24.3





GO Molecular Function

metallopeptidase activity | endopeptidase inhibitor activity | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | modified amino acid binding | cation binding | lipid binding | enzyme inhibitor activity | hydrolase activity | carbohydrate derivative binding | phospholipid binding | molecular function regulator | catalytic activity | anion binding | exopeptidase activity | glycolipid binding | dipeptidase activity | ion binding | metalloexopeptidase activity | protein binding | zinc ion binding | aminopeptidase activity | dipeptidyl-peptidase activity | metallodipeptidase activity | phosphatidylinositol binding | transition metal ion binding | GPI anchor binding | cysteine-type endopeptidase regulator activity involved in apoptotic process | peptidase inhibitor activity | enzyme regulator activity | metal ion binding | peptidase activity | cysteine-type endopeptidase inhibitor activity

GO Biological Process

metallopeptidase activity | regulation of cysteine-type endopeptidase activity | endopeptidase inhibitor activity | leukotriene metabolic process | proteolysis | regulation of localization | sulfur compound metabolic process | regulation of programmed cell death | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | negative regulation of cysteine-type endopeptidase activity | glutathione metabolic process | negative regulation of cellular process | response to metal ion | response to drug | negative regulation of proteolysis | cellular process | regulation of cell motility | cellular response to nitric oxide | negative regulation of apoptotic process | regulation of proteolysis | negative regulation of cell migration | response to inorganic substance | negative regulation of cellular metabolic process | negative regulation of cell motility | cellular amino acid metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | xenobiotic metabolic process | catabolic process | cellular response to metal ion | response to stimulus | enzyme inhibitor activity | cellular response to xenobiotic stimulus | response to stress | programmed cell death | cellular response to inorganic substance | cellular nitrogen compound metabolic process | negative regulation of metabolic process | cofactor metabolic process | molecular function regulator | response to nitrogen compound | apoptotic process | sulfur amino acid metabolic process | nitrogen compound metabolic process | negative regulation of catalytic activity | antibiotic metabolic process | regulation of peptidase activity | regulation of catalytic activity | cellular response to oxidative stress | negative regulation of peptidase activity | cellular response to stress | exopeptidase activity | regulation of nitrogen compound metabolic process | cellular lactam catabolic process | regulation of cell migration | cellular amide catabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | cellular amide metabolic process | regulation of cellular component movement | response to oxidative stress | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | dipeptidase activity | regulation of cellular protein metabolic process | response to xenobiotic stimulus | cellular response to drug | metalloexopeptidase activity | regulation of cellular metabolic process | regulation of protein metabolic process | peptide metabolic process | regulation of locomotion | drug metabolic process | carboxylic acid metabolic process | aminopeptidase activity | protein metabolic process | cellular response to calcium ion | dipeptidyl-peptidase activity | metallodipeptidase activity | cellular response to reactive nitrogen species | metabolic process | negative regulation of programmed cell death | cellular response to reactive oxygen species | organic substance metabolic process | cell death | response to reactive oxygen species | negative regulation of cellular protein metabolic process | negative regulation of cellular component movement | negative regulation of protein metabolic process | icosanoid metabolic process | cysteine-type endopeptidase regulator activity involved in apoptotic process | homocysteine metabolic process | negative regulation of molecular function | organic acid metabolic process | peptidase inhibitor activity | enzyme regulator activity | regulation of endopeptidase activity | cellular modified amino acid metabolic process | heterocycle metabolic process | negative regulation of hydrolase activity | response to calcium ion | cellular metabolic process | peptidase activity | regulation of cell death | response to nitric oxide | cysteine-type endopeptidase inhibitor activity | negative regulation of cell death | negative regulation of locomotion | negative regulation of endopeptidase activity | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | apical plasma membrane | cell projection membrane | actin-based cell projection | cell | intrinsic component of membrane | intracellular organelle | apical part of cell | cell projection | plasma membrane | vesicle | extracellular exosome | anchored component of membrane | extracellular region | microvillus | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cell periphery | microvillus membrane | intracellular | cell junction | membrane