QuickView for DPYD (gene)
- Gene Symbol:
- DPYD
Homo sapiens - Full name:
- dihydropyrimidine dehydrogenase
- Synonyms:
- DHP, DHPDHASE, DPD, dihydropyrimidine dehydrogenase [NADP(+)], dihydrothymine dehydrogenase, dihydrouracil dehydrogenase
- Genomic Location:
- Chr 1: 97315887-98159203
- Description:
-
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer pa...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
TGANTCA_AP1_C , HNF1_01 , TTANTCA_UNKNOWN , IPF1_Q4 , HNF1_C , CTTTGA_LEF1_Q2 , PBX1_01 , LEF1_Q2 , CDX2_Q5 , POU1F1_Q6
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
1p21.3
GO Molecular Function
oxidoreductase activity, acting on NAD(P)H | NADP binding | cofactor binding | cation binding | dihydropyrimidine dehydrogenase (NADP+) activity | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | nucleotide binding | flavin adenine dinucleotide binding | coenzyme binding | catalytic activity | anion binding | iron-sulfur cluster binding | identical protein binding | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | NADH dehydrogenase activity | protein dimerization activity | uracil binding | 4 iron, 4 sulfur cluster binding | drug binding | dihydrouracil dehydrogenase (NAD+) activity | metal ion binding | heterocyclic compound binding | oxidoreductase activity, acting on the CH-CH group of donors | oxidoreductase activity | small molecule binding
GO Biological Process
oxidoreductase activity, acting on NAD(P)H | beta-alanine biosynthetic process | pyrimidine nucleoside metabolic process | nucleoside catabolic process | cellular process | organic substance catabolic process | dihydropyrimidine dehydrogenase (NADP+) activity | carbohydrate derivative catabolic process | deoxyribonucleoside catabolic process | thymidine metabolic process | cellular amino acid metabolic process | catabolic process | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | pyrimidine nucleobase catabolic process | thymidine catabolic process | cellular amino acid biosynthetic process | cellular nitrogen compound metabolic process | cellular biosynthetic process | nucleobase-containing compound catabolic process | drug catabolic process | regulation of neurotransmitter levels | nitrogen compound metabolic process | beta-alanine metabolic process | nucleoside metabolic process | nucleobase-containing small molecule catabolic process | small molecule metabolic process | nucleobase-containing small molecule metabolic process | neurotransmitter metabolic process | biosynthetic process | aromatic compound catabolic process | drug metabolic process | carboxylic acid metabolic process | NADH dehydrogenase activity | uracil metabolic process | metabolic process | oxidation-reduction process | nucleobase catabolic process | purine nucleobase catabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | organonitrogen compound catabolic process | uracil catabolic process | neurotransmitter biosynthetic process | pyrimidine nucleobase metabolic process | organic acid metabolic process | purine nucleobase metabolic process | carbohydrate derivative metabolic process | dihydrouracil dehydrogenase (NAD+) activity | heterocycle metabolic process | oxidoreductase activity, acting on the CH-CH group of donors | cellular metabolic process | thymine catabolic process | oxidoreductase activity | thymine metabolic process | pyrimidine nucleoside catabolic process
GO Cellular Component
cell | cytoplasm | cytosol | intracellular
